Results 271 to 280 of about 133,158,617 (301)

A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood-brain barrier.

Lab Chip
Nogueira Pinto H, Kistemaker L, Ponomarenko M, Ermakov AA, Karsten-van Diepen M, van der Pol SMA, Pasterkamp RJ, Beekhuis-Hoekstra SD, de Wit NM, van Bodegraven EJ, de Vries HE, Hol EM.   +11 more
europepmc   +1 more source

Evaluation of Human Performance Aiding Live Synthetically Engineered Bacteria in a Gut-on-a-Chip.

ACS Biomaterials Science & Engineering, 2022
Synbiotics are a new class of live therapeutics employing engineered genetic circuits. The rapid adoption of genetic editing tools has catalyzed the expansion of possible synbiotics, exceeding traditional testing paradigms in terms of both throughput and
M. Nelson, Heidi G. Coia, C. Holt, Eric S. Greenwood, L. Narayanan, P. Robinson, E. Merrill, V. Litteral, M. Goodson, R. Saldanha, Matthew W. Grogg, C. Mauzy   +11 more
semanticscholar   +2 more sources

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A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis.

Lab on a Chip, 2021
Mechanistic understanding of atherosclerosis is largely hampered by the lack of a suitable in vitro human arterial model that recapitulates the arterial wall structure, and the interplay between different cell types and the surrounding extracellular ...
Chengxun Su, N. Menon, Xiao-Han Xu, Yu-Rong Teo, Huan Cao, R. Dalan, Chor Yong Tay, Han-Wei Hou   +7 more
semanticscholar   +1 more source

A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases.

Lab on a Chip, 2020
Development of organoids and microfluidic on-chip models has enabled studies of organ-level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are primarily monolayer epithelial-endothelial co-cultures, separated by a thin ...
Joscelyn C. Mejías, Michael R Nelson, O. Liseth, K. Roy   +3 more
semanticscholar   +1 more source

Amnion-on-a-chip: modeling human amniotic development in mid-gestation from pluripotent stem cells.

Lab on a Chip, 2020
The amnion serves to create a protective environment for a growing fetus, and the study of amniotic development will greatly facilitate our understanding of normal and abnormal pregnancies.
Yujuan Zhu, Hui Wang, Fangchao Yin, Ya-Qiong Guo, Fei Li, D. Gao, Jian-Hua Qin   +6 more
semanticscholar   +1 more source

Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip.

Biomaterials, 2020
Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the leading cause of mortality worldwide. Considerable research into human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has highlighted their immense ...
J. Veldhuizen, Josh Cutts, David A. Brafman, R. Migrino, M. Nikkhah   +4 more
semanticscholar   +1 more source

Microfluidic Systems and Organ (Human) on a Chip

, 2021
Janina Bahnemann, Anton Enders, Steffen Winkler   +2 more
semanticscholar   +1 more source