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Modeling mucus physiology and pathophysiology in human organs-on-chips
Advanced Drug Delivery Reviews, 2022The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic relationships with commensal microbiome while protecting against potentially injurious environmental chemicals, toxins, and pathogens, and disruption of this layer can contribute to disease development.
Zohreh, Izadifar +15 more
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Microfabrication of human organs-on-chips
Nature Protocols, 2013'Organs-on-chips' are microengineered biomimetic systems containing microfluidic channels lined by living human cells, which replicate key functional units of living organs to reconstitute integrated human organ-level pathophysiology in vitro. These microdevices can be used to test efficacy and toxicity of drugs and chemicals, and to create in vitro ...
Dongeun, Huh +7 more
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Microfluidic Systems and Organ (Human) on a Chip
2021In the previous chapters we learned how cells are cultivated in 3D and how the surrounding gel matrix is optimized. However, to achieve even higher physiologically relevant cell culture conditions, the surrounding environment must be controlled by emerging microfluidic systems.
Bahnemann, Janina +2 more
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Science, 2020
Physiology Organ chips are devices in which epithelial and/or stromal cells are grown in a chamber filled with medium connected by a porous matrix-like membrane to another chamber lined with endothelial cells and containing a blood substitute. Depending on the cell types used and the contents of the blood substitute and medium, these chips can model ...
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Physiology Organ chips are devices in which epithelial and/or stromal cells are grown in a chamber filled with medium connected by a porous matrix-like membrane to another chamber lined with endothelial cells and containing a blood substitute. Depending on the cell types used and the contents of the blood substitute and medium, these chips can model ...
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Modelling cancer in microfluidic human organs-on-chips
Nature Reviews Cancer, 2019One of the problems that has slowed the development and approval of new anticancer therapies is the lack of preclinical models that can be used to identify key molecular, cellular and biophysical features of human cancer progression. This is because most in vitro cancer models fail to faithfully recapitulate the local tissue and organ microenvironment ...
Alexandra Sontheimer-Phelps +2 more
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Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment
Trends in Food Science & Technology, 2016Equipment and device qualification and test assay validation in the field of tissue engineered human organs for substance assessment remain formidable tasks with only a few successful examples so far. The hurdles seem to increase with the growing complexity of the biological systems, emulated by the respective models.
Sofia P, Rebelo +5 more
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Single Cell Grid Networks of Human Astrocytes On Chip
2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), 2019In this paper, we demonstrate, for the first time, how we can pattern grid networks of human hNT astrocytes on parylene-C/SiO2 substrates down to the single cell level. We demonstrate that the functionality of the astrocyte networks by calcium release on the introduction of ATP and show that this is similar to that of a control sample.
Si Li +3 more
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Development of Biomimetic Human Lung Alveolus Chip
2023The potential of physiologically relevant in vitro cell culture models for studying physiological and pathophysiological phenomena has been widely recognized as replacements for animal and conventional in vitro models. To create models that accurately replicate the structure and function of tissues and organs, it is essential to comprehend the ...
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The Ultimate Gene Gizmo: Humanity on a Chip
Science, 2003Commercial genomics reached a landmark last week. Three companies--Affymetrix, Agilent Technologies, and NimbleGen Systems--are now offering arrays covering all known human genes.
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Measurement of naproxen in human plasma by chip‐based immunoaffinity capillary electrophoresis
Biomedical Chromatography, 2006AbstractAn electrokinetic immunoassay performed in a chip‐based capillary electrophoresis system is described for the rapid measurement of naproxen in human plasma. The system employs a fluorescently labeled antibody to capture and detect the analyte of interest within a 5 min total assay time with an LOD of 0.025 µg/mL and a saturation level of 450 µg/
Terry M, Phillips, Edward F, Wellner
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