In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Customers Suffer From Employee Churn: High Turnover Makes It Harder to Provide Top Service [PDF]
, 2009 Key Findings: • As rates of voluntary turnover climb within key business units, customers are more likely to report bad customer service. • When new workers arrive, established workers have to take time away from customer service to train the
Center for Advanced Human Resource Studies, ILR School, Cornell University.
core +1 more source
The human imperative of stabilizing global climate change at 1.5°C
, 2019 Ove Hoegh‐Guldberg +20 more
openalex +2 more sources
Using Geographically Weighted Regression (GWR) to Explore Spatial Varying Relationships of Immature Mosquitoes and Human Densities with the Incidence of Dengue [PDF]
, 2011 Chia‐Hsien Lin, Tzai‐Hung Wen
openalex +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Harness the Power of Frontline Supervisors to Turn HR Policies into Performance Gains [PDF]
, 2010 Key Findings: • Frontline supervisors play a critical role in implementing HR policies by developing employees and managing performance. • Coaching counts—one-on-one feedback from frontline supervisors increases the bottom-line by improving ...
Center for Advanced Human Resource Studies, ILR School, Cornell University
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels [PDF]
, 2016 Nicolas Defarge +6 more
openalex +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
The past, present, and future of soils and human health studies [PDF]
, 2015 Eric C. Brevik, T. J. Sauer
openalex +1 more source