Results 201 to 210 of about 21,623,211 (334)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

singIST: An integrative method for comparative single-cell transcriptomics between disease models and humans. [PDF]

PLoS Comput Biol
Moruno-Cuenca A, Picart-Armada S, Bogle R, Fox J, Tsoi LC, Gudjonsson JE, Perera-Lluna A, Fernández-Albert F.   +7 more
europepmc   +1 more source

Nag op 'n kaal plein.

Tydskrif vir Letterkunde, 2018
Thys Human
doaj  

Vlakwater

Tydskrif vir Letterkunde, 2016
Thys Human
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Human Condition

Academic Psychiatry, 2017
A. J. McLean
semanticscholar   +1 more source

Non-invasive environmental DNA sampling reveals tuberculosis risks at the human - Great Ape Interface in Africa. [PDF]

Emerg Microbes Infect
Kalalizi E, Flores L, Pérez-Sancho M, Perelló A, Herranz C, Herrera L, Romero B, Kaleme P, García-Seco T, Kujirakwinja D, Kalonji A, Kashongwe Z, Birembano-Machara F, Baganda D, Nkonzi P, Del Burgo IV, Gal FL, De La Fuente J, Domínguez L, Gortázar C.   +19 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The WU-Minn Human Connectome Project: An overview

NeuroImage, 2013
D. C. Essen, Stephen M. Smith, D. Barch, Timothy Edward John Behrens, E. Yacoub, K. Uğurbil   +5 more
semanticscholar   +1 more source

Environmental degradation as a recipe for emerging viral diseases: implications for global health. [PDF]

One Health Outlook
Hudu SA, Jimoh AO, Amin-Nordin S, Syed Hassan S.   +3 more
europepmc   +1 more source