Results 221 to 230 of about 24,361,159 (357)

An LC-MS/MS Method for the Quantitation of Metabolites M9, M12, and M20 of Bexicaserin in Human Cerebrospinal Fluid. [PDF]

Biomed Chromatogr
Kallem RR, Chan R, Yeager M, Neal K, Fletcher K, Srinivas NR.   +5 more
europepmc   +1 more source

A Dot/Icm‐translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa [PDF]

, 2008
Souhaila Al Khodor, Christopher T. D. Price, Fabien Habyarimana, Awdhesh Kalia, Yousef Abu Kwaik   +4 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Response Strategies of Giant Panda, Red Panda, and Forest Musk Deer to Human Disturbance in Sichuan Liziping National Nature Reserve. [PDF]

Biology (Basel)
Duan M, Dai Q, Luo W, Fu Y, Feng B, Zhou H.   +5 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Gammaretrovirus Infections in Humans in the Past, Present, and Future: Have We Defeated the Pathogen? [PDF]

Pathogens
van der Kuyl AC.
europepmc   +1 more source

The role of science and technology education at network age population for sustainable development of Bangladesh through human resource advancement [PDF]

, 2009
Gazi Mahabubul Alam
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Vlakwater

Tydskrif vir Letterkunde, 2016
Thys Human
doaj   +1 more source

A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses [PDF]

, 2016
Natividad Gomez-Roman, Katrina H. Stevenson, Lesley Gilmour, Graham Hamilton, Anthony J. Chalmers   +4 more
openalex   +1 more source