Results 91 to 100 of about 3,649,021 (290)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

KUR’AN’A GÖRE KADER MESELESİNE BİR BAKIŞ

open access: yesBartın Üniversitesi İslami İlimler Fakültesi Dergisi, 2017
İnsanlık tarihinin en önemli meselelerinden biri kader meselesidir. Buna bağlı olarak herhangi bir oluşun özellikle de insan tercihlerinin, ezelden Allah tarafından belirlenmiş olup olmadığı ya da bilinip bilinmediği konusu ilk sırayı alır. Bu çalışmanın
Mustafa Özden
doaj  

Over-Imitation in the Kalahari Desert and the Origins of Human Cultural Cognition [PDF]

open access: yes, 2009
Children grow up in environments saturated with tools and objects which they must learn to use. One of the most efficient ways in which children do this is by imitating.
Keyan Tomaselli, Mark Nielsen
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Extending the use of plateau-escaping macro-actions in planning [PDF]

open access: yes, 2006
Many fully automated planning systems use a single, domain independent heuristic to guide search and no other problem specific guidance. While these systems exhibit excellent performance, they are often out-performed by systems which are either given ...
Smith, Amanda
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Remote Real-Time Collaboration Platform enabled by the Capture, Digitisation and Transfer of Human-Workpiece Interactions [PDF]

open access: yes, 2015
In this highly globalised manufacturing ecosystem, product design and verification activities, production and inspection processes, and technical support services are spread across global supply chains and customer networks.
Advikolanu, Yohann   +5 more
core  

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