Results 241 to 250 of about 2,199,898 (317)

The Gut Microbiome of the Asiatic Toad (<i>Bufo gargarizans</i>) Reflects Environmental Changes and Human Activities. [PDF]

Ecol Evol
Kang X, Shao M, Jiang J, He L, Lu Y, Song J, Xu J, Fan Z.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Quantitative impacts of climate change and human activities on grassland growth in Xinjiang, China. [PDF]

Front Plant Sci
Rui H, Luo B, Wang Y, Zhu L, Zhu Q.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Unraveling the invasion patterns of <i>Galinsoga quadriradiata</i> in mountain ranges: Insights from human activities, phenotypic and genetic variations. [PDF]

Plant Divers
Chen Y, Song X, Liu G, Wang J, Zhang C, Chang X, Zou J, Zhu Z.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Editorial: Exploring the effects of human activities and climate change on soil microorganisms in grasslands. [PDF]

Front Microbiol
Tang S, Struik PC, Ren J, Wang C, Jin K.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Editorial: Degradation, conservation and ecological restoration of seagrass beds under intensifying global changes

Frontiers in Marine Science
Shaochun Xu, Shaochun Xu, Shaochun Xu, Shaochun Xu, Richard K. F. Unsworth, Richard K. F. Unsworth, Juan D. Gaitan-Espitia, Yi Zhou, Yi Zhou, Yi Zhou, Yi Zhou   +10 more
doaj   +1 more source

How Human Activities Affect Groundwater Storage. [PDF]

Research (Wash D C)
Zhao Y, Zhang M, Liu Z, Ma J, Yang F, Guo H, Fu Q.   +6 more
europepmc   +1 more source