Results 251 to 260 of about 2,199,898 (317)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Chemical characteristics of groundwater and surface water affected by human activities in the upper Jinzi River Basin, China. [PDF]

Sci Rep
Zhang X, Zhang Y, Gui Y, Sun R, Li J, Wu Q, Ding Y, Chen K.   +7 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Using Ecological Modeling to Study the Response of Distribution Dynamics of <i>Paraglenea fortunei</i> (Coleoptera: Cerambycidae) to Human Activities and Climate Change to in Northeast Asia. [PDF]

Ecol Evol
Wang P, Zhang L, Li J, Yang C, Xie G, Wang W.   +5 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Hydrochemical evolution and formation mechanism of groundwater affected by human activities in Zhangxuan basin, northwest of Yanshan mountains, China. [PDF]

PLoS One
Ma M, Yu Y, Yan B, Tuo Y, Gai J.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Vision Sensor for Automatic Recognition of Human Activities via Hybrid Features and Multi-Class Support Vector Machine. [PDF]

Sensors (Basel)
Kamal S, Alhasson HF, Alnusayri M, Alatiyyah M, Aljuaid H, Jalal A, Liu H.   +6 more
europepmc   +1 more source

Impact of Human Activities on Woody Vegetation in Gallery Forests in the Mandara Mountains (Far North, Cameroon). [PDF]

ScientificWorldJournal
Fanday H, Tchobsala.
europepmc   +1 more source

Qinghai Province (Tibetan Plateau): Quantifying the Influence of Climate Change and Human Activities on Vegetation Net Primary Productivity and Livestock Carrying Capacity Growth Potential. [PDF]

Biology (Basel)
Wei Q, Zhou B, Wang W.
europepmc   +1 more source