Results 231 to 240 of about 13,117,722 (295)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Editorial: Degradation, conservation and ecological restoration of seagrass beds under intensifying global changes

Frontiers in Marine Science
Shaochun Xu, Shaochun Xu, Shaochun Xu, Shaochun Xu, Richard K. F. Unsworth, Richard K. F. Unsworth, Juan D. Gaitan-Espitia, Yi Zhou, Yi Zhou, Yi Zhou, Yi Zhou   +10 more
doaj   +1 more source

How Human Activities Affect Groundwater Storage. [PDF]

Research (Wash D C)
Zhao Y, Zhang M, Liu Z, Ma J, Yang F, Guo H, Fu Q.   +6 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Editorial: Exploring the effects of human activities and climate change on soil microorganisms in grasslands. [PDF]

Front Microbiol
Tang S, Struik PC, Ren J, Wang C, Jin K.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Unraveling the invasion patterns of <i>Galinsoga quadriradiata</i> in mountain ranges: Insights from human activities, phenotypic and genetic variations. [PDF]

Plant Divers
Chen Y, Song X, Liu G, Wang J, Zhang C, Chang X, Zou J, Zhu Z.   +7 more
europepmc   +1 more source

Chemical characteristics of groundwater and surface water affected by human activities in the upper Jinzi River Basin, China. [PDF]

Sci Rep
Zhang X, Zhang Y, Gui Y, Sun R, Li J, Wu Q, Ding Y, Chen K.   +7 more
europepmc   +1 more source

Using Ecological Modeling to Study the Response of Distribution Dynamics of <i>Paraglenea fortunei</i> (Coleoptera: Cerambycidae) to Human Activities and Climate Change to in Northeast Asia. [PDF]

Ecol Evol
Wang P, Zhang L, Li J, Yang C, Xie G, Wang W.   +5 more
europepmc   +1 more source

Hydrochemical evolution and formation mechanism of groundwater affected by human activities in Zhangxuan basin, northwest of Yanshan mountains, China. [PDF]

PLoS One
Ma M, Yu Y, Yan B, Tuo Y, Gai J.
europepmc   +1 more source