Results 171 to 180 of about 16,739,739 (312)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Commentary: Deep learning in obsessive-compulsive disorder: a narrative review

Frontiers in Psychiatry
Olga Kashevarova, Galina Portnova, Guzal Khayrullina, Guzal Khayrullina, Krystsina Liaukovich, Ekaterina Proshina, Anastasia Gaidareva, Anastasia Gaidareva, Rohit Verma, Rupali Bhardwaj, Olga Martynova, Olga Martynova   +11 more
doaj   +1 more source

GlucoSense: early diabetes risk assessment via fusion of human activity recognition and glucose prediction. [PDF]

Front Digit Health
Khan MFI, Uddin MZ, Shamsul Alam M, Baselizadeh A, Masum AKM.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Deep learning for stress oriented human activity recognition. [PDF]

Front Digit Health
Hamza M, Uddin N, Anjum G, Anas M, Gabol U, Saddaf Khan N.   +5 more
europepmc   +1 more source

Human Activity and Climate Change

In this activity, students will examine graphs of greenhouse gas (GHG) emissions and their increases associated with human activity. They will focus on carbon dioxide, methane, nitrous oxide, chlorofluorocarbons (CFCs), and ozone.

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Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Minimal Sensor Configuration for Human Activity Recognition in Patients With Hip Osteoarthritis: Proof-of-Concept Study. [PDF]

JMIR Biomed Eng
Alalem N, Duay V, Di Benedetto A, Rose-Dulcina K, Hannouche D, Armand S, Gasparutto X.   +6 more
europepmc   +1 more source

A human-computer interactive approach based on activity-section analysis for BPR

, 2000
In any business process reengineering (BPR) project, a thorough understanding of various tasks and activities of the organization is required. Very often this idea is captured using a simple flow chart or static representation diagram.
Ip, M.H., Fung, R.Y.K., Wang DW(汪定伟), Zhiwen Tang   +3 more
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