Results 231 to 240 of about 38,354 (289)

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

open access: yesThe FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang   +15 more
wiley   +1 more source

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma

open access: yesInternational Journal of Cancer, Volume 158, Issue 12, Page 3252-3267, 15 June 2026.
What's new? Oncolytic viruses are a promising immunotherapeutic approach against many malignancies. However, it is unclear whether repeated doses have improved therapeutic value or may trigger greater side effects, especially in patients with hepatocellular carcinoma whose liver is chronically damaged.
Karen J. Scott   +10 more
wiley   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

open access: yes
Transfusion, EarlyView.
Thane Kubik   +2 more
wiley   +1 more source

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

open access: yesThe FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu   +9 more
wiley   +1 more source

Genotyping of human adenoviruses circulating in Southwest India. [PDF]

open access: yesVirusdisease, 2016
Akhil C   +4 more
europepmc   +1 more source

Vaccination and transfusion safety at the time of expanding use of live attenuated vaccines

open access: yes
Vox Sanguinis, EarlyView.
Pierre Tiberghien   +4 more
wiley   +1 more source

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