Results 51 to 60 of about 38,375 (244)
Neoplasia: An International Journal for Oncology Research, 2005 Oncolytic adenoviruses are being tested as potential therapies for human malignant tumors, including gliomas. Here we report for the first time that a mutation in the E1A gene results in low levels of ElA protein, conditioning the replication of mutant ...
Hong Jiang +10 more
doaj +1 more source
Development of a WNT-selective oncolytic adenovirus for imaging the therapy of colorectal cancers. [PDF]
, 2008 PhDIntroduction: The concept of oncolytic adenoviruses has been validated in preclinical studies but clinical trials have demonstrated that the virus spread remains limited and the virus fails to infect all cancer cells in a tumour.
Peerlinck, Inge D L +1 more
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m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis
Advanced Science, EarlyView.This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang +26 more
wiley +1 more source
Identification of adenovirus E1A gene regions involved in chemosensitisation of prostate cancer cells [PDF]
, 2009 PhDReplication-selective adenoviruses are promising anti-cancer therapies (virotherapy). Viruses can be engineered to selectively target cancer cells by deleting viral genes involved in cell cycle regulation.
Rota, Enrique Miranda
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Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses [PDF]
, 2017 Near-atomic resolution structure of species-D adenovirus 26 (HAdV-D26) reveals structural conservation among human adenoviruses.
Xiaodi Yu +6 more
core +1 more source
Adenovirus-Associated Influenza-Like Illness among College Students, Pennsylvania, USA
Emerging Infectious Diseases, 2018 Among students with influenza-like illness at a Pennsylvania college student health center during 2016–2017, 44 (15%) of 288 with respiratory specimens tested positive for human adenovirus (HAdV).
Holly M. Biggs +5 more
doaj +1 more source
Advanced Science, EarlyView.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
Human adenoviruses role in ophthalmic pterygium formation [PDF]
, 2015 Background: Ophthalmic pterygium is a common benign lesion of unknown origin and the pathogenesis might be vision-threatening. This problem is often associated with exposure to solar light. Recent evidence suggests that potentially oncogenic viruses such
Moradi, A. +10 more
core +1 more source
Advanced Science, EarlyView.Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han +20 more
wiley +1 more source
SUSCEPTIBILITY OF HUMAN ADENOVIRUSES TO INTERFERON. [PDF]
, 1969 SUSCEPTIBILITY OF HUMAN ADENOVIRUSES TO ...
JAMES GERARD. GALLAGHER (7984166)
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