Results 41 to 50 of about 38,354 (289)

The Role of Hexon Protein as a Molecular Mold in Patterning the Protein IX Organization in Human Adenoviruses. [PDF]

J Mol Biol, 2017
Reddy VS.
europepmc   +2 more sources

Adenoviruses [PDF]

, 2019
Adenoviruses are among the most studied and at the same time most mysterious of viruses. In this book, the authors highlight the achievements in the study of animal and human adenoviruses, chemotherapy of adenovirus infections, and the development in ...

core   +1 more source

A Human In Vitro Model to Study Adenoviral Receptors and Virus Cell Interactions

Cells, 2022
To develop adenoviral cell- or tissue-specific gene delivery, understanding of the infection mechanisms of adenoviruses is crucial. Several adenoviral attachment proteins such as CD46, CAR and sialic acid have been identified and studied.
Raphael L. Tsoukas, Wolfram Volkwein, Jian Gao, Maren Schiwon, Nora Bahlmann, Thomas Dittmar, Claudia Hagedorn, Eric Ehrke-Schulz, Wenli Zhang, Armin Baiker, Anja Ehrhardt   +10 more
doaj   +1 more source

Chimpanzee Adenoviruses Are Related to Four Subgenera of Human Adenoviruses

Intervirology, 1989
Nine adenovirus strains isolated from chimpanzees were studied with regard to their relatedness to each other and to human adenovirus prototypes by neutralization and hemagglutination inhibition. The strains belonged to six serotypes, and all of them were clearly related to, but not identical to human adenoviruses of subgenus A, B, C, or E respectively.
R, Wigand, M, Mauss, T, Adrian
openaire   +2 more sources

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
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The Oncogenicity of Human Adenoviruses in Hamsters

Experimental Biology and Medicine, 1968
In 1962 we reported that human adenovirus type 12 induces undifferentiated sarcomas at the site of injection into newborn hamsters in high incidence and after a very short latent period (1,2). Extensive attempts to recover virus from such tumors have been negative in this and several other laboratories (3,4), although Connor et al.
J J, Trentin, G L, Van Hoosier, L, Samper   +2 more
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Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells [PDF]

, 2006
Swiss Cancer League, Swiss National Science Foundation and SNSF NCCR Molecular Oncology ProgrammeBackground: The Wnt signaling pathway is activated by mutations in the APC and beta-catenin genes in many types of human cancer.
Homicsko, Krisztian, Pittet Anne-Laure, Christophe Fuerer, Lukashev, Alexander N., Homicsko Krisztian, Alexander N Lukashev, Fuerer Christophe, Anne-Laure Pittet, Iggo, Richard D., Fuerer, Christophe, Pittet, Anne-Laure, Richard D Iggo, Lukashev Alexander N, Iggo Richard D, Krisztian Homicsko   +14 more
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Pyrogenicity of human adenoviruses

Journal of General Virology, 2000
High doses (>1·56×107 p.f.u.) of purified preparations of human adenovirus types 3, 5 and 8 exhibited definite pyrogenic activity when injected intravenously into rabbits. Complete pyrogenic tolerance was obtained not only with homologous types but also with heterologous types of adenovirus.
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Chimpanzee Adenovirus Antibodies in Humans, Sub-Saharan Africa

Emerging Infectious Diseases, 2006
Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses.
Zhiquan Xiang, Yan Li, Ann Cun, Wei Yang, Susan Ellenberg, William M. Switzer, Marcia L. Kalish, Hildegund C.J. Ertl   +7 more
doaj   +1 more source

Chimpanzee adenoviral vectors as vaccines – challenges to move the technology into the fast lane

Expert Review of Vaccines, 2017
Introduction: In recent years, replication-defective chimpanzee-derived adenoviruses have been extensively evaluated as genetic vaccines. These vectors share desirable properties with human adenoviruses like the broad tissue tropism and the ease of large-
Alessandra Vitelli, Antonella Folgori, Elisa Scarselli, Stefano Colloca, Stefania Capone, Alfredo Nicosia   +5 more
doaj   +1 more source