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Integrating oncolytic adenoviruses into combination cancer therapy: Mechanisms, advances and clinical outlook [PDF]

Clinical and Translational Medicine
Background Cancer represents a major global public health issue, and recent research has focused on improving the efficacy of existing therapeutic approaches. In this context, oncolytic viruses have emerged as promising treatment options for advanced and
Vlad Iova, Gilda Mihaela Iova, Mihail Silviu Tudosie, Ioana Scrobota, Catalin Gabriel Smarandache   +4 more
doaj   +2 more sources

Epidemiological analysis of six common respiratory pathogen infections in children in Chengdu from 2022 to 2024 [PDF]

Frontiers in Pediatrics
BackgroundThis study aimed to describe the epidemiological characteristics of six common respiratory pathogens in children admitted to Chengdu Women's and Children's Central Hospital.MethodsA total of children with respiratory tract infection symptoms ...
Chunyuan Wang, Mengjun Luo, Shuzhe Yang
doaj   +2 more sources

Two Novel Adenovirus Vectors Mediated Differential Antibody Responses via Interferon-α and Natural Killer Cells

Microbiology Spectrum, 2023
Recombinant adenovirus vectors have been widely used in vaccine development. To overcome the preexisting immunity of human adenovirus type 5 (Ad5) in populations, a range of chimpanzee or rare human adenovirus vectors have been generated.
Peng Zou, Panli Zhang, Qitao Deng, Cong Wang, Shengxue Luo, Ling Zhang, Chengyao Li, Tingting Li   +7 more
doaj   +1 more source

Trends in Viral Respiratory Infections During COVID-19 Pandemic, South Korea

Emerging Infectious Diseases, 2021
We compared weekly positivity rates of 8 respiratory viruses in South Korea during 2010–2019 and 2020. The overall mean positivity rate for these viruses decreased from 54.7% in 2010–2019 to 39.1% in 2020. Pandemic control measures might have reduced the
Sujin Yum, Kwan Hong, Sangho Sohn, Jeehyun Kim, Byung Chul Chun   +4 more
doaj   +1 more source

Binding Mechanism Elucidation of the Acute Respiratory Disease Causing Agent Adenovirus of Serotype 7 to Desmoglein-2

Viruses, 2020
The study of viruses causing acute respiratory distress syndromes (ARDS) is more essential than ever at a time when a virus can create a global pandemic in a matter of weeks.
Marc-André Hograindleur, Gregory Effantin, Daphna Fenel, Caroline Mas, André Lieber, Guy Schoehn, Pascal Fender, Emilie Vassal-Stermann   +7 more
doaj   +1 more source

Assembly of Adenoviruses [PDF]

Journal of Virology, 1973
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of purified incomplete particles of adenoviruses type 2 and 3 revealed that core proteins V and VII and capsid proteins VI, VIII, and X were absent in these particles, but they contained polypeptides not present in complete particles.
B, Sundquist, E, Everitt, L, Philipson, S, Hoglund   +3 more
openaire   +2 more sources

Effects of Contamination of Freshwater Habitat With Common Heavy Metals and Anions on the Prevalence of Human Adenoviruses and Enteroviruses

Frontiers in Public Health, 2021
The occurrence and survival of enteric viruses in open surface waters can be impacted by a host of factors including fecal emission levels, seasonal variations, virus stability and the physicochemical parameters.
Michael Opere Wasonga, John Maingi, Ombori Omwoyo   +2 more
doaj   +1 more source

Viral diarrhea in structure of acute intestinal infections in children

Журнал инфектологии, 2014
In order to evaluate contribution of the viral agents into the etiological structure of acute intestinal infection in children during the period of increase in morbidity rate due to intestinal infections from January 2009 to January 2010 there were ...
M. U. Asilova, E. I. Musabaev, G. B Ubaydullaeva   +2 more
doaj   +1 more source

Serological Array-in-Well Multiplex Assay Reveals a High Rate of Respiratory Virus Infections and Reinfections in Young Children

mSphere, 2019
Serological assays are used to diagnose and characterize host immune responses against microbial pathogens. Microarray technologies facilitate high-throughput immunoassays of antibody detection against multiple pathogens simultaneously. To improve survey
Anna Kazakova, Laura Kakkola, Henna Päkkilä, Tamara Teros-Jaakkola, Tero Soukka, Ville Peltola, Matti Waris, Ilkka Julkunen   +7 more
doaj   +1 more source

GAMER-Ad: a novel and rapid method for generating recombinant adenoviruses

Molecular Therapy: Methods & Clinical Development, 2021
Oncolytic adenoviruses have become ideal agents in the path toward treating cancer. Such viruses have been engineered to conditionally replicate in malignant cells in which certain signaling pathways have been disrupted.
Firas Hamdan, Beatriz Martins, Michaela Feodoroff, Yvonne Giannoula, Sara Feola, Manlio Fusciello, Jacopo Chiaro, Gabriella Antignani, Mikaela Grönholm, Erkko Ylösmäki, Vincenzo Cerullo   +10 more
doaj   +1 more source