Results 161 to 170 of about 9,633,208 (257)

Other title: Employment Law's Clark Kent; Other title: ow You Can be a Superhero, Too!

, 2017
"7/7/2017."Kansas Human Rights Commission -- Harassment: Demonstrating "Reasonable Care" -- The Complaint Process -- The Investigation -- Disability: Engaging in the Interactive ...
Kansas Human Rights Commission.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using machine learning to extract information and predict outcomes from reports of randomised trials of smoking cessation interventions in the Human Behaviour-Change Project. [PDF]

Wellcome Open Res, 2023
West R, Bonin F, Thomas J, Wright AJ, Mac Aonghusa P, Gleize M, Hou Y, O'Mara-Eves A, Hastings J, Johnston M, Michie S.   +10 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Keeping Cats Safe at Home (KCSAH): Lessons Learned from a Human Behaviour Change Campaign to Reduce the Impacts of Free-Roaming Domestic Cats. [PDF]

Animals (Basel)
Ma GC, Gates MC, Littlewood KE, Zito S, Kennedy BPA.   +4 more
europepmc   +1 more source

Research on the Training and Management of Industrializing Workers in Prefabricated Building with Machine Vision and Human Behaviour Modelling Based on Industry 4.0 Era. [PDF]

Comput Intell Neurosci, 2022
Wang J, Song Y, Yuan C, Guo F, Huangfu Y, Liu Y.   +5 more
europepmc   +1 more source

From human factors to HSI and beyond: operation centers and control rooms

, 2014
Currently, Human Factors does not just cover human performance and human centred design but also the evaluation and influencing of human behaviour in complex environments.
Brake, G.M. te, Post, W.M., Bronkhorst, A.W.   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Ecological brain: reframing the study of human behaviour and cognition. [PDF]

R Soc Open Sci
Vigliocco G, Convertino L, De Felice S, Gregorians L, Kewenig V, Mueller MAE, Veselic S, Musolesi M, Hudson-Smith A, Tyler N, Flouri E, Spiers HJ.   +11 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source