Results 101 to 110 of about 24,686,030 (394)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Transactional Education and Transactional Educators: Fostering the Habit of “Using Intelligence Fully” [PDF]
, 2003 This paper calls into question the assumptions implicit in many traditional theories of moral agency; namely, the assumption that moral agency requires the agent to be disinterested, disengaged, and psychically distant in order to be a good moral agent ...
Lowe, Barbara J.
core +1 more source
EXPOSURE OF THE PUBLIC OF THE LENINRGAD REGION DUE TO THE NATURAL SOURCES OF IONIZING RADIATION
Радиационная гигиена, 2018 This study is focused on the analysis of the results of the radiation-hygienic passportisation and the Joint state system of control and accounting of the individual doses of the public from natural sources of ionizing radiation in the Leningrad region ...
O. A. Istorik +4 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Playing with the “Playing God” [PDF]
, 2017 Some philosophers and theologians have argued against the idea of Human Enhancement, saying that human beings should not play God. A closer look, however, might reveal that the question of who is playing Whom is far from being so ...
Andreeva, E., Dabbagh, Hossein
core
Do Human Beings Stop Existing at Their Deaths in Aquinas’ Account
, 2023 Khanh Trinh
openalex +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Exercise’s impact on lung cancer molecular mechanisms: a current overview
Frontiers in OncologyLung cancer is the major cause of cancer-related deaths worldwide with an estimated 1.8 million deaths and 2.4 million new cases in 2022. Poor cardiorespiratory fitness, dyspnea and fatigue are the common features in lung cancer patients, partially ...
Annamaria Mancini +14 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Радиационная гигиена, 2019 According to the Decree of the President of the Russian Federation №585, 13.10.2018, the main approaches to the provision of the radiation safety of the public of the Russian Federation from the use of the sources of ionizing radiation in medicine are ...
G. G. Onischenko +10 more
doaj +1 more source