Results 81 to 90 of about 2,100,730 (306)

Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals [PDF]

, 2017
In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine "resistin pathway".
Antonucci, Alessandra, Copetti, Massimiliano, De Bonis, Concetta, Di Paola, Rosa, Marucci, Antonella, Menzaghi, Claudia, Ortega Moreno, Lorena, Salvemini, Lucia, Trischitta, Vincenzo   +8 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Acetylcholinesterase and butyrylcholinesterase levels of healthy volunteers who not exposed to pesticides in Chiang Mai Province

Journal of Associated Medical Sciences, 2017
Background: Food contamination of pesticides, especially organophosphate and carbamate, leads to changes in cholinesterase level. Thus, using of previous reference value of enzymes to predict the severity of pesticides exposure may be misleading ...
Supawatchara Singhatong
doaj  

Insulin-Like Peptide 3 (INSL3) Serum Concentration During Human Male Fetal Life

Frontiers in Endocrinology, 2019
Context: Insulin-like peptide 3 (INSL3), a protein hormone produced by Leydig cells, may play a crucial role in testicular descent as male INSL3 knockout mice have bilateral cryptorchidism.
Steven M. Harrison, Nicol Corbin Bush, Yi Wang, Zachary R. Mucher, Armando J. Lorenzo, Gwen M. Grimsby, Bruce J. Schlomer, Erika E. Büllesbach, Linda A. Baker   +8 more
doaj   +1 more source

Urinary Neutrophil Gelatinase-associated Lipocalin as a Marker for Identification of Acute Kidney Injury and Recovery in Dogs with Gentamicin-induced Nephrotoxicity. [PDF]

, 2016
BackgroundAcute kidney injury (AKI) is associated with high mortality rates in dogs, which may be a consequence of late recognition using traditional diagnostic tests.
Cowgill, LD, Kanakubo, K, Kowalkowski, KL, LeRoy, BE, Palm, CA, Segev, G, Westropp, JL   +6 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Phenotypic variation of Streptococcus Suis Serotype 2 isolated from Northern Thai patients characterized by survival in human blood and serum

Journal of Associated Medical Sciences, 2016
Introduction: Streptococcus suis is one of the most important zoonotic pathogens worldwide. It can cause a wide range of diseases both in pigs and human including meningitis, endocarditis, arthritis and pneumonia.
Jeeraphong Khikhuntod, Kwanjit Duangsonk, Manu Deeudom, Hathairat Thananchai   +3 more
doaj  

Enhancing the wound healing process through local injection of exosomes derived from blood serum: An in vitro and in vivo assessment

Regenerative Therapy
Introduction: The skin plays a crucial role as a protective barrier against external factors, but disruptions to its integrity can lead to wound formation and hinder the natural healing process.
Mehdi Rasti, Amir Hossein Parniaei, Leila Dehghani, Salar Nasr Esfahani, Hossein Mirhendi, Vida Yazdani, Vajihe Azimian Zavareh   +6 more
doaj   +1 more source

Pathogen Inactivation of Human Serum Facilitates its Clinical Use for Islet Cell Culture and Subsequent Transplantation

Cell Transplantation, 2011
Serum is regarded as an essential supplement to promote survival and growth of cells during culture. However, the potential risk of transmitting diseases disqualifies the use of serum for clinical cell therapy in most countries. Hence, most clinical cell
Magnus U. Ståhle, Daniel Brandhorst, Olle Korsgren, Folke Knutson   +3 more
doaj   +1 more source

Blood Serum Stimulates p38-Mediated Proliferation and Changes in Global Gene Expression of Adult Human Cardiac Stem Cells

Cells, 2020
During aging, senescent cells accumulate in various tissues accompanied by decreased regenerative capacities of quiescent stem cells, resulting in deteriorated organ function and overall degeneration.
Anna L. Höving, Kazuko E. Schmidt, Madlen Merten, Jassin Hamidi, Ann-Katrin Rott, Isabel Faust, Johannes F. W. Greiner, Jan Gummert, Barbara Kaltschmidt, Christian Kaltschmidt, Cornelius Knabbe   +10 more
doaj   +1 more source