Results 101 to 110 of about 2,100,730 (306)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease

Clinical Proteomics, 2019
Background Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is a challenge due to an extremely large dynamic range, as exemplified by a small subset of
Kaushik Kumar Dey, Hong Wang, Mingming Niu, Bing Bai, Xusheng Wang, Yuxin Li, Ji-Hoon Cho, Haiyan Tan, Ashutosh Mishra, Anthony A. High, Ping-Chung Chen, Zhiping Wu, Thomas G. Beach, Junmin Peng   +13 more
doaj   +1 more source

Seasonal variation of 25-hydroxyvitamin D3 levels in meat of Moroccan onehumped dromedary camels (Camelus dromedaries) [PDF]

, 2015
In human, vitamin D which derives from the action of sunlight in the skin and dietary intake is of great importance for health, and may be influenced by the season.
Abouhafs, Rachid, Bargaa, Rita, El Abbadi, Najia, El Khasmi, Mohammed, Faye, Bernard, Mohamed, F., Tahri, El Hassan   +6 more
core  

A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae [PDF]

, 2013
The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks.
Chiers, Koen, Geldhof, Peter, Masure, Dries, Van Den Broeck, Wim, Vercruysse, Jozef, Vlaminck, Johnny, Wang, Tao   +6 more
core   +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Association Between Neopterin Production and other Parameters in a Population of Blood Donors

Pteridines, 2002
Neopterin is released from human monocyte-derived macrophages preferentially upon stimulation with the Thlcell cytokine interferon-γ. In humans, increased concentrations of neopterin in serum and urine have been found in viral infections including human ...
Schennach Harald, Murr Christian, Gächter Elmar, Mayersbach Peter, Schönitzer Diether, Fuchs Dietmar   +5 more
doaj   +1 more source

Genetic variants of Y chromosome are associated with a protective lipid profile in black men [PDF]

, 2008
Objective— Gender and ethnicity modulate the phenotypic expression of cardiovascular risk factors. In particular, men are at higher risk of developing cardiovascular diseases compared to women, whereas black populations of African origin display reduced ...
Alfonso Siani, Alfonso Siani, Fabio Lauria, Fabio Lauria, Gianvincenzo Barba, Gianvincenzo Barba, Michelle A. Miller, Michelle A. Miller, O Gianfrancesco, O Gianfrancesco, Paola Russo, Paola Russo, Pasquale Strazzullo, Pasquale Strazzullo, Sharada Karanam, Sharada Karanam, Teresa Esposito, Teresa Esposito   +17 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Enhancement of signal intensity of elements in human blood serum using a metal mesh-enhanced CO2 laser-induced breakdown spectroscopy in ambient He gas

Talanta Open
Accurate and reliable identification and analysis of the elemental composition of human blood serum is of utmost importance. The present investigation included the analysis of human blood serums for elemental composition using a metal mesh-supported CO2 ...
Ali Khumaeni, Wahyu Setia Budi, Rinda Hedwig, Kazuyoshi Kurihara, Masahiko Tani, Koo Hendrik Kurniawan   +5 more
doaj   +1 more source

Specialties of Blood Serum Structurization Under Some Physiological Conditions [PDF]

Journal of Stress Physiology & Biochemistry, 2018
Background: it is well-known that physiological stress agents can to produce a significant response of regulatory systems. At the same time, the nature of metabolic shifts in the organism during significant physical exertion and emotional stress has been
Andrew K. Martusevich, Lida K. Kovaleva, Lubov M. Kozlova, Maria A. Feofilova   +3 more
doaj