Results 301 to 310 of about 9,526,153 (337)

Variability of the cardiomyocyte ploidy in normal human hearts

Virchows Archiv B Cell Pathology Including Molecular Pathology, 1992
We have performed cytophotometry for DNA in isolated myocytes of the left ventricle from 16 men, aged 19-39 years, who died from various non-cardiac or pulmonary causes. The mean ploidy of myocytes varied from 3.2-3.9 c to 6.6-7.3 c in different layers of the anterior wall of the left ventricle (where c is the haploid DNA content measured by ...
, Brodsky VYa, A L, Chernyaev, I A, Vasilyeva   +2 more
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Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract

Human Cell, 2011
Cell transplantation shows potential for the treatment of cardiac diseases. Embryonic stem cells, cord blood and mesenchymal stem cells have been suggested as sources for transplantation therapy. Because of some technical limitations with the use of stem cells, transdifferentiation of fully differentiated cells is a potentially useful alternative.
Zahra, Vojdani, Sima, Tavakolinejad, Tahereh, Talaei-Khozani, Tahereh, Esmaeilpour, Manuchehr, Rasooli   +4 more
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Cardiomyocytes from Human Embryonic Stem Cells

2006
Terminal heart failure is characterized by a significant loss of cardiac myocytes. Stem cells represent a possibility for replacing these lost myocytes but the question of which stem cells are most ideally suited for cell transplantation therapies is still being addressed.
R, Passier, C, Denning, C, Mummery
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Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes

Molecular BioSystems, 2013
Abstract Fetal (fCM) and adult cardiomyocytes (aCM) significantly differ from each other both by structure and biochemical properties. aCM own a higher mitochondrial mass compared to fCM due to increased energy demand and show a greater density and higher degree of structural organization of myofibrils.
Jaakko L O, Pohjoismäki, Marcus, Krüger, Natalie, Al-Furoukh, Anssi, Lagerstedt, Pekka J, Karhunen, Thomas, Braun   +5 more
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[The ploidy variability of human cardiomyocytes].

Biulleten' eksperimental'noi biologii i meditsiny, 1990
Unlike literature on ploidy of the human myocytes, DNA content and the number of nuclei have been revealed in the same cells. Besides, the cell ploidy were studied separately in the external, central and inner regions in the left ventricule. Considerable binucleation was revealed in normal and hypertrophic ventricles where 4c X2 was the modal cell ...
V Ia, Brodskiĭ, I A, Vasil'eva, N V, Panova, D S, Sarkisov, A M, Aref'eva   +4 more
openaire   +1 more source

Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes.

Journal of Molecular and Cellular Cardiology, 2021
A. Martyniak, K. Andrysiak, Benjamin Motais, S. Coste, P. Podkalicka, P. Ferdek, J. Stępniewski, J. Dulak   +7 more
semanticscholar   +1 more source

Reprogramming of human keratinocytes into functional cardiomyocytes

Italian Journal of Anatomy and Embryology, 2015
Purpose. Induced pluripotent stem cells (iPS) can be generated by patients intro- ducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. However, the various iPS cell lines are characterized by different properties such as differentiation efficiency and potential safety hazards.
Ghinassi, Barbara, D’Amico, Maria, Izzicupo, Pascal, Di Baldassarre, Angela   +3 more
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Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology

Nature Protocols, 2009
To date, there is no suitable in vitro model to study human adult cardiac cell biology. Although embryonic stem cells are able to differentiate into cardiomyocytes in vitro, the efficiency of this process is very low. Other methods to differentiate progenitor cells into beating cardiomyocytes rely on coculturing with rat neonatal cardiomyocytes, making
Anke M, Smits, Patrick, van Vliet, Corina H, Metz, Tom, Korfage, Joost Pg, Sluijter, Pieter A, Doevendans, Marie-José, Goumans   +6 more
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A software tool for studying the size and shape of human cardiomyocytes

Biomedical Signal Processing and Control, 2016
Abstract Background and objectives Due to development of imaging systems the amount of digital images obtained in the biological field has been growing in recent years. These images contain information that is not directly measurable, e.g. the area covered by a single cell.
Jyrki Rasku, Marisa Ojala, Risto-Pekka Pölönen, Henry Joutsijoki, Yulia Gizatdinova, Jorma Laurikkala, Kimmo Kartasalo, Katriina Aalto-Setälä, Martti Juhola   +8 more
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Variability of ploidy of human cardiomyocytes

Bulletin of Experimental Biology and Medicine, 1989
V. Ya. Brodskii, I. A. Vasil'eva, N. V. Panova, D. S. Sarkisov, A. M. Aref'eva   +4 more
openaire   +1 more source