Results 91 to 100 of about 9,004,562 (264)

An Improved Purification of Human Chorionic Gonadotropin

Endocrinologia Japonica, 1973
A newly improved method for obtaining a highly active human chorionic gonadotropin (HCG) has been developed. A crude HCG with an activity of about 3, 000 IU per mg was applied to an Amberlite CG-50 column equilibrated with 0.01 M ammonium acetate buffer, pH 5.0. This first purification procedure yielded two separate peaks. The pooled fraction under the
OKUMURA, HAJIME, NAMBA, SHUICHI, MATSUSHIMA, SANAE   +2 more
openaire   +2 more sources

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Higher LSD1 in Non‐Seminomatous Germ Cell Tumors and LSD1 Inhibition by NCL1 Suppresses Embryonal Carcinoma Growth

Cancer Science, EarlyView.
LSD1 expression was higher in non‐seminomatous than in seminomatous testicular germ cell tumor components. In embryonal carcinoma models, selective LSD1 inhibition by NCL1 induced epigenetic and apoptotic responses, reduced viability including in cisplatin‐adapted cells, and suppressed early xenograft outgrowth, supporting LSD1 as a potential ...
Nobuhiko Shimizu, Toshiki Etani, Taku Naiki, Aya Naiki‐Ito, Yosuke Sugiyama, Takashi Nagai, Akihiro Murakami, Hiroyuki Kato, Toshiharu Morikawa, Maria Aoki, Masakazu Gonda, Hiroko Suzuki, Yohei Tsubouchi, Daiki Ishikawa, Takayoshi Suzuki, Satoru Takahashi, Takahiro Yasui   +16 more
wiley   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Purification and Heterogeneity of Human Chorionic Gonadotropin [PDF]

A highly active preparation of human chorionic gonadotropin (HCG) has been obtained by simple methods of column chromatography on diethylaminoethyl Sephadex and Sephadex G-100. The preparation was seen by SDS-polyacrylamide gel electrophoresis to consist
菅田, 恵子, 718, SUGATA, Keiko, 719
core   +1 more source

Testosterone Replacement Therapy in Adolescents and Young Adults With Prader‐Willi Syndrome: Efficacy and Effects on Behaviour

Clinical Endocrinology, EarlyView.
ABSTRACT Context Hypogonadism in Prader‐Willi syndrome (PWS) is associated with decreased bone mineral density (BMD) in male adolescents and adults. Testosterone Replacement Therapy (TRT) improves BMD and sexual maturation, but TRT could aggravate pre‐existing challenging behaviour in male patients with PWS.
Wiebe R. Flamman, Demi J. Trueba‐Timmermans, Lionne N. Grootjen, Laura C. G. de Graaff, Joyce M. Geelen, Janielle A. E. M. van der Velden, Edmond H. H. M. Rings, Anita C. S. Hokken‐Koelega, Gerthe F. Kerkhof   +8 more
wiley   +1 more source

An unusual cause of gynaecomastia in a male

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Beta-human chorionic gonadotropin (βhCG) is normally produced by syncytiotrophoblasts of the placenta during pregnancy and aids embryo implantation.
Tejhmal Rehman, Ali Hameed, Nigel Beharry, J Du Parcq, Gul Bano   +4 more
doaj   +1 more source

Weight Regain After Incretin Treatment: The Lean Mass Deficit Hypothesis and a Role for Testosterone Combination Therapy in Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann, Zsolt Bosnyak, Richard Jones, Monica Caliber   +3 more
wiley   +1 more source

Acute Effects of Acarbose and Canagliflozin, Alone and in Combination, on Postprandial GLP‐1 and Glycaemic Responses in Post‐Bariatric Hypoglycaemia: A Randomised Crossover Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To evaluate the acute effects of acarbose and canagliflozin, alone and in combination, on postprandial total GLP‐1 and glycaemic responses during a mixed meal test in adults with post‐bariatric hypoglycaemia (PBH). Materials and Methods This single‐centre, randomised, four‐period crossover physiological study included 12 adults with PBH ...
Wei Yang, Anna Kowalka, Lara Jimenez‐Pacheco, Veronica Greener, Kleopatra Alexiadou, Ahmed Ahmed, Julia Kenkre, Chioma Izzi‐Engbeaya, Saira Hameed, Harvinder Chahal, Bernard Khoo, Tricia M.‐M. Tan   +11 more
wiley   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source