Results 191 to 200 of about 134,051 (264)

Recent advances in human cytomegalovirus: a comprehensive review of pathogenic mechanisms, virus-host interactions, and antiviral strategies. [PDF]

Front Immunol
Xia Y, Zhang J, Shui X, Wang C, Zhang S, Chai W, Yang Y, Shen L, Wang C.   +8 more
europepmc   +1 more source

Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease

iNew Medicine, EarlyView.
Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Objective Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer.
Boyu Zhang, Chunyang Zhang, Xiao Cui, Tao Xu, Xiangpeng Hu, Jiong Gu   +5 more
wiley   +1 more source

Initiation of human cytomegalovirus secondary envelopment requires the gM/gN glycoprotein complex and involves palmitoylation. [PDF]

J Virol
Cortez Rayas L, Rogg R, Voll M, Thompson C, Lieber D, Read C, von Einem J.   +6 more
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Human cytomegalovirus terminase inhibitors letermovir, tomeglovir, and the halogenated benzimidazoles modify DNA cleavage/packaging to generate a super-genomic DNA species by cleavage site skipping. [PDF]

Antiviral Res
Ourahmane A, Balalimbong DK, Sauer A, Wang JB, Al Qaffas A, Moorad R, Landis J, Dittmer DP, Dollery SJ, McVoy MA.   +9 more
europepmc   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Human cytomegalovirus strain-specific differences in protein expression of type I IFN pathway proteins do not impact virus replication. [PDF]

Access Microbiol
Latham KA, Soh TK, Stanton RJ, Bosse JB, Goodbourn S, Strang BL.   +5 more
europepmc   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Human Cytomegalovirus Antigen Presentation by HLA-G in Infected Cells. [PDF]

HLA
Altadill M, Álvarez I, Ataya M, Heredia G, Alari-Pahissa E, Muntasell A, Llano M, Fuchs J, Vilches C, Hengel H, Halenius A, López-Botet M.   +11 more
europepmc   +1 more source