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Pneumonitis in human cytomegalovirus infection

Current Infectious Disease Reports, 2006
Human cytomegalovirus (HCMV) is a beta herpes virus with a double stranded DNA genome of 240kbp. The virus is prevalent and establishes a latent infection in most adults. HCMV is an opportunistic pathogen for patients with impaired cellular immunity. HCMV pneumonia is a common presentation of HCMV disease in immunocompromised patients. The incidence of
Erik, Langhoff, Robert E, Siegel
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Consequences of human cytomegalovirus mimicry

Human Immunology, 2004
The HCMV genome has evolved with its host by incorporating a series of genes that are homologous to, or functionally mimic, cellular genes. Some are designed to counteract the stress of infection on the host cell, notably the viral antiapoptotic proteins (vICA, vMIA). Others potentially help the infected cell maintain a low immunologic profile.
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Defective virions of human cytomegalovirus

Virology, 1979
Abstract Passage of human cytomegalovirus at high multiplicity of infection generated defective virus particles which banded in CsCI at a lower buoyant density than standard virus. The DNA from defective virions banded at a lower buoyant density in CsCl than standard DNA and sedimented in sucrose gradients similar to standard DNA.
M L, Ramirez   +3 more
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Human cytomegalovirus and immunopathology

Springer Seminars in Immunopathology, 2002
J G P, Sissons   +4 more
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Construction of Recombinant Human Cytomegalovirus

2003
The use of reverse genetics to generate recombinant viruses allows the researcher to investigate the exact functional significance of particular viral genes during the virus life cycle, by means of their deletion or modification in the viral genome. These studies can extend to the introduction of viral or foreign genetic material into ectopic sites in ...
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Control of Apoptosis by Human Cytomegalovirus

2008
Caspase-dependent apoptosis has an important role in controlling viruses, and as a result, viruses often encode proteins that target this pathway. Caspase-dependent apoptosis can be activated from within the infected cell as an intrinsic response to replication-associated stresses or through death-inducing signals produced extrinsically by immune cells.
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Human cytomegalovirus vaccine

2022
KRAMARCZYK JACK F   +4 more
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Human Cytomegalovirus Infection in Transplantation

Nephron, 2008
G A, Müller   +3 more
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An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

Cell, 2018
Mathilde Foglierini   +2 more
exaly  

Human cytomegalovirus elicits fetal γδ T cell responses in utero

Journal of Experimental Medicine, 2010
David Vermijlen   +2 more
exaly  

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