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Human cytomegalovirus labyrinthitis
American Journal of Otolaryngology, 1990The purpose of this report is to present a review of the clinical and histopathologic findings in human cytomegalovirus (HCMV) labyrinthitis. Human cytomegalovirus infection was first recognized in its congenital disseminated form and, subsequently, in a subclinical form.
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Human Monoclonal Antibodies to Human Cytomegalovirus
The Journal of Infectious Diseases, 1989Human monoclonal antibodies (HMAbs) to human cytomegalovirus (HCMV) have been developed by using electric field-induced cell fusion of human B lymphocytes to the human-mouse cell line SBC-H20. By this procedure, multiple hybridomas have been produced that secrete IgG 1 HMAbs with distinct patterns of indirect immunofluorescence on HCMV-infected cells ...
S K, Foung +6 more
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Pneumonitis in human cytomegalovirus infection
Current Infectious Disease Reports, 2006Human cytomegalovirus (HCMV) is a beta herpes virus with a double stranded DNA genome of 240kbp. The virus is prevalent and establishes a latent infection in most adults. HCMV is an opportunistic pathogen for patients with impaired cellular immunity. HCMV pneumonia is a common presentation of HCMV disease in immunocompromised patients. The incidence of
Erik, Langhoff, Robert E, Siegel
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Inactivation of human cytomegalovirus by phytohemagglutinin
Archives of Virology, 1978Human cytomegalovirus (CMV) was inactivated by treatment with phytohemagglutinin (PHA) in contrast to herpes simplex virus (HSV), which was not. Approximately 90% of infectivity was lost following exposure of CMV to PHA. Greater reduction of infectivity, more than 99%, was obtained following pretreatment of cells with PHA than by direct mixture of the ...
M, Ito, L, Girvin, A L, Barron
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Human cytomegalovirus infection and atherothrombosis
Journal of Thrombosis and Thrombolysis, 2011Vascular endothelium, as a key regulator of hemostasis, mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. Endothelial dysfunction caused by acute or chronic inflammation, such as in atherosclerosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites, and at ...
Popović, Milan +5 more
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Consequences of human cytomegalovirus mimicry
Human Immunology, 2004The HCMV genome has evolved with its host by incorporating a series of genes that are homologous to, or functionally mimic, cellular genes. Some are designed to counteract the stress of infection on the host cell, notably the viral antiapoptotic proteins (vICA, vMIA). Others potentially help the infected cell maintain a low immunologic profile.
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Human cytomegalovirus and immunopathology
Springer Seminars in Immunopathology, 2002J G P, Sissons +4 more
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Construction of Recombinant Human Cytomegalovirus
2003The use of reverse genetics to generate recombinant viruses allows the researcher to investigate the exact functional significance of particular viral genes during the virus life cycle, by means of their deletion or modification in the viral genome. These studies can extend to the introduction of viral or foreign genetic material into ectopic sites in ...
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Epigenetics: Future Prospective in Human Disorders and Therapeutics
Medical Epigenetics, 2021Shriram N Rajpathak
exaly
Immunobiology of Infection with Human Cytomegalovirus
1983Publisher Summary This chapter discusses the immunobiology of infection with human cytomegalovirus. It focuses on relevant problems of the immunobiology of infection with human cytomegalovirus (HCMV) and on the interactions between HCMV and the cellular components of the immune system.
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