Results 281 to 290 of about 8,732,052 (351)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Early Postnatal Infection With Human Cytomegalovirus Has Long-Term Consequences on Brain Structure of Former Preterm Born Children. [PDF]

Brain Behav
Müller M, Lidzba K, Gaser C, Hauser TK, Goelz R, Hamprecht K, Wilke M.   +6 more
europepmc   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Human cytomegalovirus-encoded G protein-coupled receptor (GPCR) UL78 regulates viral reactivation. [PDF]

J Virol
Osanyinlusi SA, Baruah V, Groves IJ, Kulp KH, Krishna BA, O'Connor CM.   +5 more
europepmc   +1 more source

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Investigating the Influence of Network Ties on Frugal Innovation Through Resource Bricolage: Insights From a Resource‐Constrained Environment

Creativity and Innovation Management, EarlyView.
ABSTRACT In resource‐constrained environments, frugal innovation has emerged as an essential entrepreneurial strategy. It allows firms to develop efficient, affordable and sustainable solutions to meet the needs of low‐income consumer markets. This increasing demand necessitates a deeper understanding of the mechanisms that foster frugal innovation ...
Chunyan Li, Mohsin Shafait, Weiming Li, Haibing Liu   +3 more
wiley   +1 more source

A New Next-Generation Sequencing Approach in Human Cytomegalovirus for the Identification of Antiviral Resistance Mutations and Genotypic Classification. [PDF]

J Med Virol
Arnedo-Muñoz M, Prats-Méndez I, Gónzalez-Sánchez A, Martín MC, Rando-Segura A, Arcos IL, Nadal-Barón P, Saubi N, Mendoza-Palomar N, Bernat-Sole M, Albasanz-Puig A, Piñana M, Andrés C, Melendo-Pérez S, Larrosa N, Antón A, Esperalba J.   +16 more
europepmc   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Human cytomegalovirus infection-induced lymphocytosis diagnosed by metagenomic next-generation sequencing: a case report and literature review. [PDF]

Front Immunol
Zhang S, Sun L, Wang L, Liu Y, Tan G, Liu T, Yang W, Liu X.   +7 more
europepmc   +1 more source

Human cytomegalovirus promotes <i>de novo</i> PC synthesis during early virus replication. [PDF]

J Virol
Kline I, Mokry RL, Xi Y, Passols Manzano M, Layesa S, Sohrab Ali N, Moy MA, Goodrum FD, Purdy JG.   +8 more
europepmc   +1 more source