Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Analisis Pengaruh Pertumbuhan Ekonomi , Kemiskinan Dan Pengangguran Terhadap Indeks Pembangunan Manusia (IPM) Di Wilayah Subosukawonosraten [PDF]
, 2016 Human development is a process of development that aims to be able to have more choices, particularly in income, health and education. One criterion can be seen through the Human Development Index.
, Ir. Maulidyah Indira Hasmarini, MS. +1 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Global incidence and mortality trends of corpus uteri cancer and associations with gross domestic product, human development index, lifestyle, and metabolic risk factors [PDF]
, 2023 Junjie Huang +10 more
openalex +1 more source
The Human Development Index Adjusted for Efficient Resource Utilization [PDF]
human development index, data envelopment analysis, efficiency, congestion and scale ...
Arcelus, F.J. +2 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Discrimination reported by people with schizophrenia: cross-national variations in relation to the Human Development Index. [PDF]
Epidemiol Psychiatr Sci, 2023 Gronholm PC +3 more
europepmc +1 more source
Smooth Support Vector Machine (SSVM) for classification of Human Development Index [PDF]
, 2019 Moh. Yamin Darsyah +4 more
openalex +1 more source
Inequality Adjustment Criteria for the Human Development Index [PDF]
Our goal is to analyse the inequality aspects of Human Development Index and to propose a new aggregation function that can adjust it by considering inequality penalisation.
Enrico Casadio Tarabusi, Giulio Guarini
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