Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Association between the Human Development Index and Confirmed COVID-19 Cases by Country. [PDF]
Healthcare (Basel), 2022 Heo MH +4 more
europepmc +1 more source
Impact Analysis of Changes in Human Resource Capital on Economic Development - from Gravely Underdeveloped to Highly Developed Societies [PDF]
This research encompasses 177 countries around the world with the data on human resource variables for the year 2005. The countries have been put into four groups: gravely underdeveloped, developing, developed, and highly developed.
Boris Crnkovic, Zeljko Pozega
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Favorable cervical cancer mortality-to-incidence ratios of countries with good human development index rankings and high health expenditures. [PDF]
BMC Womens Health, 2023 Shen TT, Long CY, Wu MP.
europepmc +1 more source
Human Development: beyond the HDI [PDF]
The well-known Human Development Index (HDI) encompasses only three rather basic aspects of human welfare. This paper aims to go beyond this, by identifying 11 categories of human development.
Gustav Ranis, Frances Stewart and Emma Samman
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Does club convergence matter? Empirical evidence on inequality in the human development index among Indian states. [PDF]
Humanit Soc Sci Commun, 2023 Nag A, Pradhan J.
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The relationship between maternal death due to COVID-19 and the human development index in East Java, Indonesia. [PDF]
J Public Health Res, 2023 Prasetyo B +7 more
europepmc +1 more source