Results 191 to 200 of about 25,111,230 (304)

Human Development Index Is Associated with COVID-19 Case Fatality Rate in Brazil: An Ecological Study. [PDF]

Int J Environ Res Public Health, 2022
Palamim CVC, Boschiero MN, Valencise FE, Marson FAL.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Association between the Human Development Index and the burden of major gastrointestinal cancers: results from Global Burden of Disease 2021. [PDF]

Gastroenterol Hepatol Bed Bench
Azizmohammad Looha M, Saberi Shahrbabaki A, Yoosefi S, Javadi S, Pourhoseingholi MA, Moradi A.   +5 more
europepmc   +1 more source

Is there an association between COVID-19 mortality and Human development index? The case study of Nigeria and some selected countries. [PDF]

BMC Res Notes, 2022
Ameye SA, Ojo TO, Adetunji TA, Awoleye MO.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Consequences of Data Error in Aggregate Indicators: Evidence from the Human Development Index [PDF]

This paper examines the consequences of data error in data series used to construct aggregate indicators. Using the most popular indicator of country level economic development, the Human Development Index (HDI), we identify three separate sources of ...
Chong, Howard, Wolff, Hendrik, Auffhammer, Maximilian   +2 more
core  

Trends in net survival from cervical cancer in a Brazilian state with medium Human Development Index. [PDF]

Sci Rep
da Silva BEB, Di Carlo V, Minicozzi P, Ssenyonga N, Khan Baloch F, Matz M, Coleman MP, Allemani C, Lima CA.   +8 more
europepmc   +1 more source

Influence of Population Size, the Human Development Index and the Gross Domestic Product on Mortality by COVID-19 in the Southeast Region of Brazil. [PDF]

Int J Environ Res Public Health, 2022
Groppo MF, Groppo FC, Figueroba SR, Pereira AC.   +3 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Trends and patterns of global health risk factors (2015-2019): a composite index approach across 100 countries stratified by human development index groups. [PDF]

J Health Popul Nutr
Junaid KP, Kiran T, Gupta M, Kishore K, Siwatch S.   +4 more
europepmc   +1 more source