Results 101 to 110 of about 2,748,543 (304)

Confronting colonial history: toward healing, just, and equitable Indigenous conservation futures

Ecology and Society
Against the backdrop of growing concerns for environmental and social justice, interest in developing effective strategies that support social and ecological resilience and recovery are mounting.
Tamara J Layden, Dominique M David-Chavez, Emma Galofré García, Gemara L. Gifford, Anna Lavoie, Erin R Weingarten, Sara P Bombaci   +6 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

How Modelers Model: the Overlooked Social and Human Dimensions in Model Intercomparison Studies. [PDF]

Environ Sci Technol, 2022
Albanito F, McBey D, Harrison M, Smith P, Ehrhardt F, Bhatia A, Bellocchi G, Brilli L, Carozzi M, Christie K, Doltra J, Dorich C, Doro L, Grace P, Grant B, Léonard J, Liebig M, Ludemann C, Martin R, Meier E, Meyer R, De Antoni Migliorati M, Myrgiotis V, Recous S, Sándor R, Snow V, Soussana JF, Smith WN, Fitton N.   +28 more
europepmc   +1 more source

The transformation of the human dimension in the cyberspace [PDF]

AI & SOCIETY, 2012
In the very interdisciplinary tradition of AI & Society, this issue covers a diversity of topics ranging from mindloading, ‘moral subject’ and human dignity and autonomy, organisation as a cognitive machine, the dilemma of boundaries between femininity and masculinity in the cyberspace, knowledge sharing for sustainable development, the emerging ...
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Research Agenda to Better Understand the Human Dimensions of Energy Transitions. [PDF]

Front Psychol, 2021
Steg L, Perlaviciute G, Sovacool BK, Bonaiuto M, Diekmann A, Filippini M, Hindriks F, Bergstad CJ, Matthies E, Matti S, Mulder M, Nilsson A, Pahl S, Roggenkamp M, Schuitema G, Stern PC, Tavoni M, Thøgersen J, Woerdman E.   +18 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ecological and human dimensions of avocado expansion in México: Towards supply-chain sustainability. [PDF]

Ambio, 2022
Denvir A, Arima EY, González-Rodríguez A, Young KR.   +3 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Introduction to special section on wildlife agency organizational change: Embracing the challenge of adaptive wildlife conservation in the United States

Conservation Science and Practice, 2022
Michael J. Manfredo, Tara L. Teel
doaj   +1 more source