Results 91 to 100 of about 2,748,543 (304)

The Serums Tool-Chain:Ensuring Security and Privacy of Medical Data in Smart Patient-Centric Healthcare Systems [PDF]

, 2019
Digital technology is permeating all aspects of human society and life. This leads to humans becoming highly dependent on digital devices, including upon digital: assistance, intelligence, and decisions.
2019 IEEE International Conference on Big Data (Big Data), Arredouani, R., Belk, M., Blackledge, E., Bowles, J.K.F., Fidas, C., Given-Wilson, T., Huang, W., Janjic, V., Kumar, M., Legay, A., Pitsillides, A., Rossbory, M., Silvina, A., Stylianou, G., Vermeulen, A.F., Vinov, M.   +16 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Country Patterns of Behaviour on Broader Dimensions of Human Development [PDF]

The paper adopts a more expansive definition of Human Development than that encompassed by the Human Development Index and explores alternative patterns of country behavior in terms of this broader definition.
Gustav Ranis, Frances Stewart and Emma Samman
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Improving Representation of Human Well-Being and Cultural Importance in Conceptualizing the West Hawai‘i Ecosystem

Frontiers in Marine Science, 2019
Ecosystem-based management approaches are increasingly used to address the critical linkages between human and biophysical systems. Yet, many of the social-ecological systems (SES) frameworks typically used in coastal and marine management neither ...
Kirsten M. Leong, Supin Wongbusarakum, Supin Wongbusarakum, Rebecca J. Ingram, Rebecca J. Ingram, Alexander Mawyer, Melissa R. Poe   +6 more
doaj   +1 more source

Incorporating human dimensions is associated with better wildlife translocation outcomes. [PDF]

Nat Commun, 2023
Serota MW, Barker KJ, Gigliotti LC, Maher SML, Shawler AL, Zuckerman GR, Xu W, Verta G, Templin E, Andreozzi CL, Middleton AD.   +10 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The history of natural history and race: Decolonizing human dimensions of ecology. [PDF]

Ecol Appl, 2023
Miriti MN, Rawson AJ, Mansfield B.
europepmc   +1 more source

Ethics, space, and somatic sensibilities: comparing relationships between scientific researchers and their human and animal experimental subjects [PDF]

, 2011
Drawing on geographies of affect and nature-society relations, we propose a radical rethinking of how scientists, social scientists, and regulatory agencies conceptualise human and animal participants in scientif ic research. The scientific rationale for
Birke L, Boo M J, Buchanan-Smith H M, Butler R, Calarco M, Ehni H, FAWC, Fenwick N P, Grandin T, Grosz E, Haraway D, Harlow H, Hinchliffe S, Jones O, Katz J, Keller E F, Latour B, Lawler J, Leach M, Lorimer J, Nast H J, Paterson M, RCN, RCN, Roe E, Rudge T, Russell W M S, Singer P, Stengers I, Thrift N, Vorstenbosch J M C, Wemelsfelder F, Whatmore S, Wolfe C   +33 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source