Results 71 to 80 of about 2,748,543 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Assimilation of Immigrants: Implications for Human Capital Accumulation of the Second Generation [PDF]

Immigrants assimilate in various dimensions at different rates. Moreover, in each of these dimensions they assimilate at rates that may differ from those of their children.
Slobodan Djajic
core  

Precision trimmer aids in preparing biomedical specimen blocks for ultrathin sectioning [PDF]

, 1967
Precision trimmer, which neatly trims biomedical specimen blocks for ultrathin sectioning, eliminates the risk of human error. Four inches in diameter and 3 inches in height, it supports the block and serves as a support for a cutting tool and can be ...
Tahmisian, T. N.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Cost–benefit analysis as a decision tool for effective conservation planning—The case of the Nyerere Selous‐Udzungwa wildlife corridor in Tanzania

Conservation Science and Practice
Cost benefit analysis (CBA) is used in many fields to ensure efficient allocation of scarce resources but is rarely applied in conservation. By using a common metric to evaluate projects in complex social‐ecological systems, CBA can help to maximize the ...
Tom Hilton, Josephine B. Smit, Trevor Jones, Joseph Mwalugelo, Kim Lim, Andrew Seidl, Kelly W. Jones, Brett Bruyere, Jonathan Salerno   +8 more
doaj   +1 more source

Understanding landowner intentions to create early successional forest habitat in the northeastern United States

Wildlife Society Bulletin, 2016
Early successional forest habitat (ESH) and associated wildlife species in the northeastern United States are in decline. One way to help create early successional forest conditions is engaging private forest landowners in even‐aged forest management ...
Ashley A. Dayer, Richard C. Stedman, Shorna B. Allred, Kenneth V. Rosenberg, Angela K. Fuller   +4 more
doaj   +1 more source

Ethical decision making [PDF]

, 2011
The self-centeredness of modern organizations leads to environmental destruction and human deprivation. The principle of responsibility developed by Hans Jonas requires caring for the beings affected by our decisions and actions.
Zsolnai, László
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Communicating about zoonotic disease: Strategic considerations for wildlife professionals

Wildlife Society Bulletin, 2011
A set of interrelated social and environmental changes have accelerated the transmission of wildlife‐associated infectious diseases around the world. Emerging infectious disease (EID) events take a heavy toll on human health and have significant global ...
Daniel J. Decker, William F. Siemer, Margaret A. Wild, Kevin T. Castle, David Wong, Kirsten M. Leong, Darrick T. N. Evensen   +6 more
doaj   +1 more source

Exploring the link between energy security and subjective well-being: a study of 22 nations

Energy, Sustainability and Society, 2019
Background Energy has long been recognized as foundational for well-being, and recent work, has documented a link between access to energy services and health.
Adam Mayer, E. Keith Smith
doaj   +1 more source