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The promise of human embryonic stem cells
Best Practice & Research Clinical Obstetrics & Gynaecology, 2004Pluripotency refers to the ability of a cell to give rise to cells that originate from all three germ layers. Among the available human pluripotent cells, human embryonic stem cells (hESCs) are considered to have the greatest probability for practical clinical application because of their simple propagation and stability in culture.
Sharon, Gerecht-Nir +1 more
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Culture of human embryonic stem cells
Nature Methods, 2005The successful culture and maintenance of human embryonic stem cells (HESCs) offers great promise for furthering our basic understanding of many regulatory and developmental processes, and for developing effective clinical applications for treating, even correcting, genetic disorders.
Gerald, Schatten +4 more
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Human Embryonic Stem Cell Therapy
Theological Studies, 2001The author presents an overview (completed on September 15, 2001) of three issues involved in the ethics of human embryonic stem cell therapy: the ethical implications of some of the scientific issues involved, the specific ethical issues of the moral standing of the early human embryo and the problem of cooperation, and a consideration of two public ...
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The Tumorigenicity of Human Embryonic Stem Cells
2008Human embryonic stem cells (HESCs) are the in vitro descendants of the pluripotent inner cell mass (ICM) of human blastocyst stage embryos. HESCs can be kept undifferentiated in culture or be differentiated to tissues representing all three germ layers, both in vivo and in vitro.
Barak, Blum, Nissim, Benvenisty
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Nucleofection of Human Embryonic Stem Cells
2008Human embryonic stem cells (HESCs) are widely used as a model system for human cell type specification. Genetic modification forms a valuable tool for HESC technology, as it provides the basis for lineage selection, i.e., the purification of a specific cell type after differentiation.
Henrike, Siemen +4 more
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Human embryonic stem cell and embryonic germ cell lines
Trends in Biotechnology, 2000Undifferentiated human embryonic stem (ES) cells and embryonic germ (EG) cells can be cultured indefinitely and yet maintain the potential to form many or all of the differentiated cells in the body. Human ES and EG cells provide an exciting new model for understanding the differentiation and function of human tissue, offer new strategies for drug ...
J A, Thomson, J S, Odorico
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Nucleofection of Human Embryonic Stem Cells
2011The ability to realize the full potential of human pluripotent stem cells (hPSCs) as tools for -understanding human development and advancing the field of regenerative medicine is dependent on efficient methods to genetically manipulate these cells. There are several methods for introducing foreign DNA into cells such as electroporation, lipid-based ...
Helen, Fong +3 more
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Derivation of Human Embryonic Stem Cells
2017Embryonic stem cells (ESCs) represent a mainstay for pluripotent stem cell research and development (R&D) and provide tangible opportunities for clinical translation including cell therapies and drug discovery. Moreover, in spite of the discovery of induced pluripotent stem cells (iPSCs), ESCs are an essential reference point, against which other ...
Crook, Jeremy Micah +3 more
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Developments in human embryonic stem cells
Reproductive BioMedicine Online, 2005My task today is to describe the properties of stem cells speaking from the perspective of an investigator familiar with mammalian embryos and also working on human embryonic stem cells. My laboratory is based in the Department of Surgery and the Cambridge Stem Cell Institute, University of Cambridge, where you can find more information about ourselves
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Human embryonic stem cells: An introduction
Human Fertility, 2002Stem cell biology is currently one of the most promising areas of scientific development, possibly leading to new therapies for many diverse medical problems. A stem cell is a cell that has the potential to differentiate into other cell types and stem cell biology investigates the processes by which this differentiation is controlled.
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