Results 81 to 90 of about 14,089,637 (300)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Brachytherapy Workflow Practices: Analysis of Different Workflow Scenarios in Patients With Cervical Cancer and Impact on IGBT Implementation—An IAEA Study

JCO Global Oncology
PURPOSEThe workflow of brachytherapy (BT) is an essential aspect of treatment to consider in image-guided brachytherapy (IGBT). It has an overarching effect influencing patient throughput and the number of cancer treatments that can be performed as it ...
Sandra Ndarukwa, Jerickson Abbie Flores, Eduardo Rosenblatt, Daniel Berger, Kamal Akbarov, Natasha Hedden, Supriya Chopra, Varsha Hande, Alfredo Polo Rubio   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

PET-guided therapy: synergies, strategies, and future directions in external beam radiation therapy and radiopharmaceutical therapy

Frontiers in Medicine
Positron Emission Tomography (PET) has evolved from a purely diagnostic modality into a cornerstone of precision radiation oncology. PET now informs patient selection, target delineation, treatment personalization, and post-therapy evaluation across ...
May Abdel-Wahab, Francesco Giammarile
doaj   +1 more source

Numerical analysis of hygrothermal environment and energy conservation in biophilic building by coupling zonal energy simulation and computational fluid dynamics [PDF]

E3S Web of Conferences
Biophilic design is an emerging trend that artificially creates natural environments inside buildings, including greenery and water. In our previous study, field measurements revealed that an artificial waterfall, as a biophilic element, has a ...
Yang Xianzhe, Yoo Sung-Jun, Choi Younhee, Arima Yusuke, Ozaki Akihito   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Structure‐Driven Smart Textiles for Self‐Powered Wearable Systems

Small Structures
Smart textiles are increasingly transitioning from passive substrates into structurally engineered, self‐powered systems, driving the next generation of wearable technologies.
Hye‐Ji Ryu, Sol Lee, Sang‐Woo Kim
doaj   +1 more source

Proof of Energy (Human Energy)

Proof of Energy: Universal Framework for Human Energy Conversion and Ethical Blockchain Integration DescriptionThe Proof of Energy (PoE) framework introduces a universal physical equation for quantifying, storing, and rewarding all forms of human-generated energy—kinetic, thermal, biochemical, electrical, and vibrational—expressed in Joules.
openaire   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source