Results 151 to 160 of about 18,710,371 (326)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Humana.Mente: Journal of Philosophical Studies, 2014 The essay is subdivided into three parts. In the first and introductory one the current debate on human enhancement is presented, with specific reference to its interdisciplinary characteristics and to the aspects which explicitly challenge “the human ...
Alberto Pirni
doaj
Miranda: Revue Pluridisciplinaire du Monde AnglophoneThis paper investigates the portrayal of life as a universal principle in contemporary North American speculative fiction, examining narratives that leverage the “greater good” of human survival to promote the idea of human enhancement.
Loredana Filip
doaj +1 more source
Enhancing the collectivist critique: accounts of the human enhancement debate. [PDF]
Med Health Care Philos, 2021 Johnson T.
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Why catastrophic events, human enhancement and progress in robotics may limit individual health rights. [PDF]
Monash Bioeth Rev, 2022 Szocik K.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Degree of enhancement: A theoretical and formal definition
Frontiers in Psychology, 2023 Federico Cassioli +3 more
doaj +1 more source
Man-machine interactive imaging and data processing using high-speed digital mass storage [PDF]
The role of vision in teleoperation has been recognized as an important element in the man-machine control loop. In most applications of remote manipulation, direct vision cannot be used.
Alsberg, H., Nathan, R.
core +1 more source