Results 141 to 150 of about 18,710,371 (326)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

'Beyond' Human Enhancement - Taking the Developing Country's Perspective Seriously. [PDF]

Asian Bioeth Rev, 2022
Sachdev V.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Eyes and movement differences in unconscious state during microscopic procedures

Scientific Reports
Microsurgery is one of the techniques that is increasingly being adopted in many surgical fields. However, the acquisition and transfer of microsurgical skills primarily depend on experience.
Akiko Fujita, Shintaro Oyama, Masahiro Tatebe, Shingo Shimoda, Katsuhiro Tokutake, Michiro Yamamoto, Hitoshi Hirata   +6 more
doaj   +1 more source

Unveiling the right to self-transformation and self-enhancement: exploring Transhumanism and its impact on human rights and the future of humanity

Deusto Journal of Human Rights
The time to discuss, contemplate and philosophize about Transhumanism has inevitably come. Thanks to technology which continues to transform human lives in enormous ways.
Lisang Nyathi
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Anthropological Arguments in the Ethical Debate about Human Enhancement

Humana.Mente: Journal of Philosophical Studies, 2014
The paper discusses the role of anthropological arguments in contemporary ethics as exemplified in the current debate about biotechnological human enhancement interventions. Anthropological arguments refer to a normative conception of what it means to be
Jan-Christoph Heilinger
doaj  

A novel logarithmic spiral design for proximal interphalangeal joint arthroplasty

Scientific Reports
This study evaluated a novel implant for proximal interphalangeal (PIP) joint arthroplasty that we designed according to the principles of a logarithmic spiral. The design addresses the limitations of current implants that poorly replicate natural finger
Hitoshi Hirata, Shigeru Kurimoto, Hidemasa Yoneda, Yasuharu Koike, Renita Sirisena, Shingo Shimoda   +5 more
doaj   +1 more source

The final frontier: what is distinctive about the bioethics of space missions? The cases of human enhancement and human reproduction. [PDF]

Monash Bioeth Rev, 2023
Szocik K, Reiss MJ.
europepmc   +1 more source