Mining and development : examining the effectiveness of mining company community development intervention in New Ireland Province, Papua New Guinea : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Development Studies at Massey University, Manawatu, New Zealand [PDF]
, 2018 This thesis explores the effectiveness of mining company contributions to development within the gold mining communities of Lihir and Simberi islands, in New Ireland Province, Papua New Guinea (PNG).
Richardson, Emma
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Pioneering neurohackers: between egocentric human enhancement and altruistic sacrifice. [PDF]
Front Neurosci, 2023 Seyfried G, Youssef S, Schmidt M.
europepmc +1 more source
Etika lidského vylepšování a liberální eugenika [PDF]
, 2014 [The Ethics of Human Enhancement and Liberal Eugenics] The paper deals with the ethics of biotechnological enhancement of human qualities such as intelligence, health and lifespan.
Hribek, Tomas
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Conceptual Origins of the Transhumanist Paradigm in the Alchemical Tradition
RUDN Journal of PhilosophyThis work analyzes alchemical doctrine through the lens of ideas that correlate with the theoretical constructs of transhumanism. It is shown that alchemy, a complex and contradictory cultural phenomenon that existed in various civilizations over long ...
Ekaterina N. Gnatik
doaj +1 more source
Life extension: a biomedical goal?
Swiss Medical Weekly, 2011 The potential for development of biomedical technologies capable of extending the human lifespan raises at least two kinds of question that it is important both to distinguish and to connect with one another: scientific, factual questions regarding the
G Barazzetti, M Reichlin
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Humana.Mente: Journal of Philosophical Studies, 2014 The expression “human enhancement” could be placed in the ontological, cognitive, and symbolic dimension in which we conceive and experience the faculty, that is constitutive of human beings, of giving name and thus consistence to things, relations and ...
Barbara Henry
doaj
Detection of Rehabilitation Training Effect of Upper Limb Movement Disorder Based on MPL-CNN
SensorsStroke represents a medical emergency and can lead to the development of movement disorders such as abnormal muscle tone, limited range of motion, or abnormalities in coordination and balance. In order to help stroke patients recover as soon as possible,
Lijuan Shi +4 more
doaj +1 more source