Results 111 to 120 of about 18,710,371 (326)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Ethical and legal considerations of mood enhancement technology
Frontiers in Human DynamicsTechnology qualifying as human mood enhancement can be developed, on the one hand, for the well-being and mental health of their users (therapy) and, on the other hand, for changing the mood of their users above levels of normality (enhancement).
Erik Kamenjasevic
doaj +1 more source
, 2014 Two major problems persist in the debate regarding the ethics of human enhancement. First, there is a lack of discussion and agreement on a definition of human enhancement. Second, the commonly used bioethical principles of justice, safety, and autonomy are jointly insufficient to assess the morality of human enhancement.
Roduit Johann A R +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Approaching Subjectivity. On “The Dispute About Subjectivity: Interdisciplinary Perspective”
Ethics in Progress, 2018 The review paper revisits the problem of subjectivity with particular focus on the latest research in this field presented in The Dispute about Subjectivity – an Interdisciplinary Perspective, edited by Adriana Warmbier (2016). I pay special attention to
Karolina Napiwodzka
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
THE THEOLOGICAL DEBATE OVER HUMAN ENHANCEMENT: AN EMPIRICAL CASE STUDY OF A MEDIATING ORGANIZATION
Zygon, 2020 For most theologians, theology should ultimately be used by the laity and/or the public. However, the religion and science debate has not focused on the divide between theologians and the laity.
doaj +2 more sources
Frontiers in Genetics, 2017 While gene doping and other technological means of sport enhancement have become a topic of ethical debate, a major outcome from genomic research in sports is often linked to the regulation of doping.
Jaehwan Hyun
doaj +1 more source