Results 111 to 120 of about 652,882 (295)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Bioethical Silence & Black Lives
Voices in Bioethics, 2015 When confirmation was released that researchers from China had genetically modified human embryos for the first time ever, there was a sudden explosion of activity on the web from the bioethics community.
Derek Ayeh
doaj +1 more source
Pioneering neurohackers: between egocentric human enhancement and altruistic sacrifice. [PDF]
Front Neurosci, 2023 Seyfried G, Youssef S, Schmidt M.
europepmc +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Personal Identity in Enhancement [PDF]
, 2015 The aim of this paper is to introduce the concept of human enhancement, its methods and its relation to personal identity. Also several approaches to personal identity will be described.
Jana Podroužková
core
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
A “Reflexive” Approach to Human Enhancement. Some Philosophical Considerations [PDF]
, 2013 The debate on the ethical, social and legal impact of technologies enhancing human capabilities has been largely fed by philosophy and ethics scholars.
Fiorella Battaglia +3 more
core
Conceptual Origins of the Transhumanist Paradigm in the Alchemical Tradition
RUDN Journal of PhilosophyThis work analyzes alchemical doctrine through the lens of ideas that correlate with the theoretical constructs of transhumanism. It is shown that alchemy, a complex and contradictory cultural phenomenon that existed in various civilizations over long ...
Ekaterina N. Gnatik
doaj +1 more source
On the (Non-)Rationality of Human Enhancement and Transhumanism. [PDF]
Sci Eng Ethics, 2022 Lyreskog DM, McKeown A.
europepmc +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source