Results 91 to 100 of about 9,181,875 (263)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Bioethical Silence & Black Lives
Voices in Bioethics, 2015 When confirmation was released that researchers from China had genetically modified human embryos for the first time ever, there was a sudden explosion of activity on the web from the bioethics community.
Derek Ayeh
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Human enhancement drugs and new(?) research directions
, 2023 Human enhancement drugs and new(?) research ...
K Mulrooney (13505839) +2 more
core
Journal of Deliberative Democracy, 2011 Exercises intended to engage laypeople in deliberations about emerging scientific and technological issues have become very popular in recent decades. These exercises are typically organized by political or intellectual elites, and often assessed in a ...
Jason Delborne +2 more
doaj +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Neuroethical Issues in Cognitive Enhancement: the Undergraduates’ Point of View
, 2018 To date, legitimacy of the application of cognitive enhancement programs to healthy individuals is still fueling neuroethics discussions. The aim of the present investigation is analyzing naïve conceptions of the ethical implications of different prac ...
Cancer, Alice, Antonietti, Alessandro
core +1 more source
Human enhancement: a middle way? [PDF]
, 2018 Tuesday, December 11, 2018; noon to 1 p.m.; Room D1.602. "Human Enhancement: A Middle Way?". Gregory E. Kaebnick, Ph.D.; Editor, The Hastings Center Report; Research Scholar, The Hastings Center.The prospect of human enhancement--of using medical ...
Kaebnick, Gregory E.
core +1 more source
Conceptual Origins of the Transhumanist Paradigm in the Alchemical Tradition
RUDN Journal of PhilosophyThis work analyzes alchemical doctrine through the lens of ideas that correlate with the theoretical constructs of transhumanism. It is shown that alchemy, a complex and contradictory cultural phenomenon that existed in various civilizations over long ...
Ekaterina N. Gnatik
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source