Results 91 to 100 of about 18,710,371 (326)
Materials Today BioHypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (Bi2S3)-titania (TiO2) heterostructure is designed based on the excellent photothermal property of Bi2S3, which ...
Rui Chen +11 more
doaj +1 more source
The rethinking and enhancement of the natural and cultural heritage of the cultural landscapes: the case of Sečovlje and Janubio saltpans [PDF]
, 2019 Cultural landscapes represent a complex category where the nature-culture dichotomy seem to not be able to unfold the main features and the profound relations that humans have with the environment.
Abad Espinoza, Luis Gregorio
core +6 more sources
Understanding human enhancement technologies through critical phenomenology
Nursing Philosophy, 2018 Human enhancement technologies raise serious ethical questions about health practices no longer content simply to treat disease, but which now also propose to "optimize" human beings' physical, cognitive and psychological abilities.
Pierre Pariseau-Legault +2 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Transhumanism and human enhancement: A postmortem [PDF]
, 2015 Fil: Vaccari, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Macquarie University; Australia. Universidad Nacional de Río Negro. Sede Andina.
Vaccari, Andrés
core +1 more source
In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]
, 2005 Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ +9 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A Quest for the Essence of Human Enhancement
Yixue yu zhexueHuman enhancement refers to the practical operation and application of relevant technologies on human beings (including the physiological, cognitive, emotional and willpower dimensions), and thereby extending, replacing or updating all aspects of the ...
Xuan JIANG
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Predittività genetica e human enhancement: questioni biogiuridiche
European Journal of Privacy Law & TechnologiesIl largo ed incisivo impiego delle applicazioni tecnologiche, nei settori più diversi dell’agire umano, produce effetti impattanti e pervasivi sul soggetto e sulle situazioni esistenziali di cui è portatore, e ciò impone l’esigenza di rimodulare la ...
Susanna Cappuccio
doaj +1 more source