Results 71 to 80 of about 9,181,875 (263)
, 2023 in collaboration with Bonneville Environmental Foundation.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Genetic enhancement -- a threat to human rights?
, 2008 Genetic enhancement is the modification of the human genome for the purpose of improving capacities or 'adding in' desired characteristics. Although this technology is still largely futuristic, debate over the moral issues it raises has been significant.
Fenton, Elizabeth
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Inhibition of monocyte complement receptor enhancement by low molecular weight material from human lung cancers [PDF]
, 1981 We have studied the effect of dialysates from lung cancer homogenates to alter both the expression of complement (C3b) receptors per se and also to inhibit leucoattractant-induced enhancement of complement rosettes on monocytes from healthy individuals ...
Kay, A B, Abell, C A, Glass, E J
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Contextual and variational contrast enhancement [PDF]
, 2011 This paper proposes an algorithm which enhances the contrast of an input image using inter-pixel contextual information. The algorithm uses a two-dimensional (2D) histogram of the input image constructed using mutual relationship between each pixel and ...
Tjahjadi, Tardi +3 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Erziehung und Ritalin. Oder: Pädagogik als Human Enhancement?
, 2012 Den Menschen besser auf die sogenannte Leistungsgesellschaft vorzubereiten, kann (auch) als eine Aufgabe von Erziehung verstanden werden. Ist es hier nicht konsequent, auch auf Mittel wie Ritalin zurückzugreifen, wenn damit bessere Leistungen erzielt ...
Damberger, Thomas
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Human enhancement: vision of a better humankind? [PDF]
, 2013 Michal Stránecký - Human Enhancement: Vision of a better Humankind? Thesis in Philosophy SUMMARY: Human Enhancement: Vision of a better Humankind? This thesis deals with the problems of Human Enhancement, i.e.
Stránecký, Michal
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source