Results 61 to 70 of about 606,320 (250)
The better human, the better than human: Limits of enhancement [PDF]
Filozofija i Društvo, 2012 Using the representations of science, fiction and science fiction, this article attempts to sketch out a certain line of development in the history of representation of the enhanced human.
Krstić Predrag
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Cognitive enhancement. Effort of definition, and methods [PDF]
Avant, 2015 The idea of cognitive enhancement refers to multifaceted and interdisciplinary approach aimed at improving human mental processes. Cognitive enhancement is the amplification or extension of core mind capacities through improvement or augmentation of ...
Artur Gunia
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Materials Today BioHypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (Bi2S3)-titania (TiO2) heterostructure is designed based on the excellent photothermal property of Bi2S3, which ...
Rui Chen +11 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A Quest for the Essence of Human Enhancement
Yixue yu zhexueHuman enhancement refers to the practical operation and application of relevant technologies on human beings (including the physiological, cognitive, emotional and willpower dimensions), and thereby extending, replacing or updating all aspects of the ...
Xuan JIANG
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Predittività genetica e human enhancement: questioni biogiuridiche
European Journal of Privacy Law & TechnologiesIl largo ed incisivo impiego delle applicazioni tecnologiche, nei settori più diversi dell’agire umano, produce effetti impattanti e pervasivi sul soggetto e sulle situazioni esistenziali di cui è portatore, e ciò impone l’esigenza di rimodulare la ...
Susanna Cappuccio
doaj +1 more source