Results 111 to 120 of about 10,990,389 (308)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Classifying polish in use-wear analysis with convolutional neural networks
Scientific ReportsLithic use-wear analysis examines micro- and macroscopic traces on tool surfaces resulting from human use and post-depositional processes. Polish, formed through surface abrasion with different materials, is a key diagnostic feature that is increasingly ...
Anastasia Eleftheriadou +3 more
doaj +1 more source
The human microbiome in evolution
BMC Biology, 2017 The trillions of microbes living in the gut-the gut microbiota-play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from human populations, placing them in the context of microbes from ...
Davenport, Emily R +5 more
openaire +5 more sources
, 2015 Children love to play. Why do they find such a frivolous activity so pleasurable and desirable? Perhaps it is not frivolous, but instead is an adaptation designed to guide proper cognitive development in human children.
Blaisdell, Aaron P,, Blaisdell, Aaron P
core
, 2020 Michael Petraglia is a prehistoric archaeologist at the Max Planck Institute for the Science of Human History! Michael's research is interdisciplinary and covers a range of subjects concerning human evolution, such as the evolution of cognition and ...
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Buffering in the intra-household allocation of scarce water in urban Dhaka, Bangladesh
Annals of Human BiologyBackground Household water insecurity is an accelerating global challenge with serious negative impacts on human health. The impacts of water insecurity can vary among household members.
Mohammad Jobayer Hossain +6 more
doaj +1 more source