Results 151 to 160 of about 871,311 (264)

Does Amyotrophic Lateral Sclerosis (ALS) Have Metabolic Causes from Human Evolution? [PDF]

Cells
Spedding M.
europepmc   +1 more source

The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution. [PDF]

Sci Rep, 2023
Ríos L, Sleeper MM, Danforth MD, Murphy HW, Kutinsky I, Rosas A, Bastir M, Gómez-Cambronero J, Sanjurjo R, Campens L, Rider O, Pastor F.   +11 more
europepmc   +1 more source

Rethinking Phylogeny and Ontogeny in Hominin Brain Evolution

, 2012
Theories of hominin and human cognitive evolution have traditionally focused on the phylogeny of the human brain, and on comparisons of human and primate brains in relation to social or ecological variables.
Coward, Fiona
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

The emergence of genetic variants linked to brain and cognitive traits in human evolution. [PDF]

Cereb Cortex
Libedinsky I, Wei Y, de Leeuw C, Rilling JK, Posthuma D, van den Heuvel MP.   +5 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Human Evolution in Backwaters, Satellites, and Republics: How Political Change Impacts Paleoanthropology in a Shifting Landscape of Winners and Losers. [PDF]

Am J Biol Anthropol
Glantz M, Radovčić D.
europepmc   +1 more source

Liver Fluke Infection Throughout Human Evolution. [PDF]

Gastro Hep Adv, 2022
Wang T, Mitchell PD.
europepmc   +1 more source

What is the Human Evolution Bed? [PDF]

, 2016
null TheHuman Evolution Bed Project Team, The Human Evolution Bed Project Team   +1 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source