Results 151 to 160 of about 3,134,757 (286)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Author Correction: Zinc isotopes from archaeological bones provide reliable trophic level information for marine mammals

Communications Biology, 2021
Jeremy McCormack, Paul Szpak, Nicolas Bourgon, Michael Richards, Corrie Hyland, Pauline Méjean, Jean-Jacques Hublin, Klervia Jaouen   +7 more
doaj   +1 more source

Evolving a Field: Can Evolutionary Theory Provide What the Study of Human Evolution Requires? [PDF]

Am J Biol Anthropol
Roseman CC, Auerbach BM.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Global impact of micronutrients in modern human evolution. [PDF]

Am J Hum Genet
Rees J, Castellano S, Andrés AM.
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology. [PDF]

Commun Biol
Moberget T, van der Meer D, Bahrami S, Roelfs D, Frei O, Kaufmann T, Fernandez-Cabello S, Kim M, Wolfers T, Diedrichsen J, Smeland OB, Shadrin A, Dale A, Andreassen OA, Westlye LT.   +14 more
europepmc   +1 more source

The Price of Human Evolution: Cancer-Testis Antigens, the Decline in Male Fertility and the Increase in Cancer. [PDF]

Int J Mol Sci, 2023
Erenpreisa J, Vainshelbaum NM, Lazovska M, Karklins R, Salmina K, Zayakin P, Rumnieks F, Inashkina I, Pjanova D, Erenpreiss J.   +9 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Correction: Back to the future: The advantage of studying key events in human evolution using a new high resolution radiocarbon method. [PDF]

PLoS One
Talamo S, Kromer B, Richards MP, Wacker L.   +3 more
europepmc   +1 more source