Results 161 to 170 of about 871,311 (264)

Investigating Development in Human Evolution: Specificities, Challenges, and Opportunities. [PDF]

Evol Anthropol
Lequin M, Colard T, Colombo A, Le Cabec A, Remy F, Schuh A.   +5 more
europepmc   +1 more source

Psychedelics, Sociality, and Human Evolution. [PDF]

Front Psychol, 2021
Rodríguez Arce JM, Winkelman MJ.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fossil ribcages of Homo sapiens provide new insights into modern human evolution. [PDF]

Commun Biol
López-Rey JM, Crevecoeur I, May H, Nadel D, Palancar CA, Gómez-Recio M, García-Martínez D, Bastir M.   +7 more
europepmc   +1 more source

Editorial: A 150 years' celebration of Darwin's book on human evolution and sexual selection: its legacy and future prospects. [PDF]

Front Psychol, 2023
Varella MAC, Salmon C, Dixson BJW, Butovskaya M, Pinto A, Pawlowski B, Weisfeld CC, Valentova JV.   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Search for Love in Human Evolution: Primate Social Bonds and a New Science of Emotion. [PDF]

Am J Biol Anthropol
Sandel AA.
europepmc   +1 more source

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution. [PDF]

Nat Rev Genet, 2023
Pollen AA, Kilik U, Lowe CB, Camp JG.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior. [PDF]

Proc Natl Acad Sci U S A
Ju XC, Lee SY, Ågren R, Machado LC, Xing J, Azama C, Roy MC, Endo T, Huttner W, Siepel A, Fukunaga I, Zeberg H, Pääbo S.   +12 more
europepmc   +1 more source