Results 161 to 170 of about 10,990,389 (308)

Frontal sinuses and human evolution. [PDF]

Sci Adv, 2022
Balzeau A, Albessard-Ball L, Kubicka AM, Filippo A, Beaudet A, Santos E, Bienvenu T, Arsuaga JL, Bartsiokas A, Berger L, Bermúdez de Castro JM, Brunet M, Carlson KJ, Daura J, Gorgoulis VG, Grine FE, Harvati K, Hawks J, Herries A, Hublin JJ, Hui J, Ives R, Joordens JA, Kaifu Y, Kouloukoussa M, Léger B, Lordkipanidze D, Margvelashvili A, Martin J, Martinón-Torres M, May H, Mounier A, du Plessis A, Rae T, Röding C, Sanz M, Semal P, Stratford D, Stringer C, Tawane M, Temming H, Tsoukala E, Zilhão J, Zipfel B, Buck LT.   +44 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Proportional limb strengths signal an adaptive shift in arboreality in early human evolution. [PDF]

Sci Adv
Carlson KJ, Ruff CB, Burgess ML, Sylvester AD, Jashashvili T, Heaton JL, Pickering TR, Sarringhaus L, Ryan TM, Beaudet A, Crompton RH, Heile AJ, Stratford D, Kuman K, Lordkipanidze D, Clarke RJ.   +15 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Burn Selection: How Fire Injury Shaped Human Evolution. [PDF]

Bioessays
Cuddihy J, Li Y, Fisher I, Takats Z, Friston D, Collins D, Vizcaychipi M, Fumagalli M, Nagy I, Leroi A.   +9 more
europepmc   +1 more source

Genomic structural variation: A complex but important driver of human evolution. [PDF]

Am J Biol Anthropol, 2023
Soto DC, Uribe-Salazar JM, Shew CJ, Sekar A, McGinty SP, Dennis MY.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression. [PDF]

Elife
Lin J, Wen Y, Tang J, Zhang X, Zhang H, Zhu H.   +5 more
europepmc   +1 more source

Nutrition and Health in Human Evolution-Past to Present. [PDF]

Nutrients, 2022
Alt KW, Al-Ahmad A, Woelber JP.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source