Results 161 to 170 of about 3,138,101 (337)

A Catalog of Coding Sequence Variations in Salivary Proteins' Genes Occurring during Recent Human Evolution. [PDF]

Int J Mol Sci, 2023
Di Pietro L, Boroumand M, Lattanzi W, Manconi B, Salvati M, Cabras T, Olianas A, Flore L, Serrao S, Calò CM, Francalacci P, Parolini O, Castagnola M.   +12 more
europepmc   +1 more source

HUMAN EVOLUTION [PDF]

Evolution, 1963
openaire   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Author Correction: Zinc isotopes from archaeological bones provide reliable trophic level information for marine mammals

Communications Biology, 2021
Jeremy McCormack, Paul Szpak, Nicolas Bourgon, Michael Richards, Corrie Hyland, Pauline Méjean, Jean-Jacques Hublin, Klervia Jaouen   +7 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Price of Human Evolution: Cancer-Testis Antigens, the Decline in Male Fertility and the Increase in Cancer. [PDF]

Int J Mol Sci, 2023
Erenpreisa J, Vainshelbaum NM, Lazovska M, Karklins R, Salmina K, Zayakin P, Rumnieks F, Inashkina I, Pjanova D, Erenpreiss J.   +9 more
europepmc   +1 more source

The Basic-Applied Continuum and the Possible Evolution of Human Operant Social and Verbal Research [PDF]

, 1982
D. F. Hake
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evolving a Field: Can Evolutionary Theory Provide What the Study of Human Evolution Requires? [PDF]

Am J Biol Anthropol
Roseman CC, Auerbach BM.
europepmc   +1 more source

Communication for collaborative computation: two major transitions in human evolution. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Dor D.
europepmc   +1 more source