Results 101 to 110 of about 8,775,558 (296)
BEHAVIOR OF HUMAN‐IMPRINTED AND HEN‐REARED WILD TURKEY POULTS
Wildlife Society Bulletin, 1975 Behavior patterns are described for human‐imprinted and hen‐reared wild turkey poults (Meleagris gallopavo silvestris) from hatching until 4 months of age. Poults fed primarily on insects during the first 5 weeks of life.
William M. Healy +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
FOR OUR CHILDREN: THE ETHICS OF ANIMAL EXPERIMENTATION IN THE AGE OF GENETIC ENGINEERING
, 2010 Preface -- 1. Introduction: animal experimentation, public opinion, and philosophical debate -- 2. Five ethical prototypes of animal experimentation -- 3. The case for "weak human priority" -- 4.
Nordgren, Anders
core
How to optimize communication about animal and animal-free research methods
Frontiers in Veterinary ScienceThere is a long-standing debate about experimental non-human animals and animal-free methods in scientific research. Among the various stakeholders involved in the debate are the scientists.
Judith Regina Homberg +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Robustness of computer algorithms to simulate optimal experimentation problems. [PDF]
Three methods have been developed by the authors for solving optimal experimentation problems. David Kendrick (1981, 2002, Ch.10) uses quadratic approximation of the value function and linear approximation of the equation of motion to simulate general ...
Michael Gapen +3 more
core
Medical practice, human experimentation and the sanctity of human life
, 2012 The need and the quest for the restoration and maintenance of good health for the people have become a priority and the business of all and sundry. This is because good health for ALL is a human necessity. This is the focus and the rationality of medical
Obioha, UP
core +1 more source
Humanidades Médicas, 2003 La ética de la experimentación con seres humanos no es sólo una de las áreas fundamentales de la bioética, sino también una de las problemáticas que le dieron origen.
Carlos M Albornoz López del Castillo +3 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source