Results 91 to 100 of about 741,034 (292)

BEHAVIOR OF HUMAN‐IMPRINTED AND HEN‐REARED WILD TURKEY POULTS

Wildlife Society Bulletin, 1975
Behavior patterns are described for human‐imprinted and hen‐reared wild turkey poults (Meleagris gallopavo silvestris) from hatching until 4 months of age. Poults fed primarily on insects during the first 5 weeks of life.
William M. Healy, Richard O. Kimmel, Ellen J. Goetz   +2 more
doaj   +1 more source

Combining Mathematical Models With Experimentation to Drive Novel Mechanistic Insights Into Macrophage Function

Frontiers in Immunology, 2019
This perspective outlines an approach to improve mechanistic understanding of macrophages in inflammation and tissue homeostasis, with a focus on human inflammatory bowel disease (IBD).
Joanneke E. Jansen, Joanneke E. Jansen, Eamonn A. Gaffney, Jonathan Wagg, Mark C. Coles   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Informed consent in experimentation involving mentally impaired persons: ethical issues

Annali dell'Istituto Superiore di Sanità, 2010
The problem of experimentation involving subjects whose mental condition prevents them from understanding information and providing proper informed consent has been addressed in various codes, declarations, conventions, treaties and regulations adopted ...
Carlo Petrini
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

CERCETAREA ŞI EXPERIMENTUL BIOMEDICAL CA VARIANTE-TIP ALE RISCULUI MEDICAL PROFESIONAL: EXPUNEREA CONDIŢIILOR DE LEGALITATE

Studia Universitatis Moldaviae: Stiinte Sociale, 2011
Improvements in medicine and surgery during the last two centuries have greatly extended the average lifetime of people and reduced the pain and disability following various injuries and diseases.
USM ADMIN
doaj  

How to optimize communication about animal and animal-free research methods

Frontiers in Veterinary Science
There is a long-standing debate about experimental non-human animals and animal-free methods in scientific research. Among the various stakeholders involved in the debate are the scientists.
Judith Regina Homberg, Aldert H. Piersma, Aldert H. Piersma, Cyrille A. M. Krul, Lisa Genzel, Anne Kienhuis, Ellen ter Gast, Monique Wolvekamp   +7 more
doaj   +1 more source

Human experimentation [PDF]

Global Bioethics, 1997
info:eu-repo/semantics ...
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

How to produce more biomass for direct seeding mulched based cropping system in sub-saharian Africa ? Example in North Cameroun [PDF]

, 2010
In North Cameroon, from 2001 to 2006, more than 250 farmers tried direct seeding mulchbased cropping systems (DMC) in their fields. DMC systems were based on farmer traditional rotation i.e. cereal//cotton.
Balarabe, Oumarou, Naudin, Krishna
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