Results 71 to 80 of about 207,063 (262)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Visual Interface Evaluation for Wearables Datasets: Predicting the Subjective Augmented Vision Image QoE and QoS

Future Internet, 2017
As Augmented Reality (AR) applications become commonplace, the determination of a device operator’s subjective Quality of Experience (QoE) in addition to objective Quality of Service (QoS) metrics gains importance. Human subject experimentation is common
Brian Bauman, Patrick Seeling
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

BEHAVIOR OF HUMAN‐IMPRINTED AND HEN‐REARED WILD TURKEY POULTS

Wildlife Society Bulletin, 1975
Behavior patterns are described for human‐imprinted and hen‐reared wild turkey poults (Meleagris gallopavo silvestris) from hatching until 4 months of age. Poults fed primarily on insects during the first 5 weeks of life.
William M. Healy, Richard O. Kimmel, Ellen J. Goetz   +2 more
doaj   +1 more source

Ethics of Human Experimentation [PDF]

BMJ, 1964
B M, BENNETT, E, NAKAMURA
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combining Mathematical Models With Experimentation to Drive Novel Mechanistic Insights Into Macrophage Function

Frontiers in Immunology, 2019
This perspective outlines an approach to improve mechanistic understanding of macrophages in inflammation and tissue homeostasis, with a focus on human inflammatory bowel disease (IBD).
Joanneke E. Jansen, Joanneke E. Jansen, Eamonn A. Gaffney, Jonathan Wagg, Mark C. Coles   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

CERCETAREA ŞI EXPERIMENTUL BIOMEDICAL CA VARIANTE-TIP ALE RISCULUI MEDICAL PROFESIONAL: EXPUNEREA CONDIŢIILOR DE LEGALITATE

Studia Universitatis Moldaviae: Stiinte Sociale, 2011
Improvements in medicine and surgery during the last two centuries have greatly extended the average lifetime of people and reduced the pain and disability following various injuries and diseases.
USM ADMIN
doaj  

How to optimize communication about animal and animal-free research methods

Frontiers in Veterinary Science
There is a long-standing debate about experimental non-human animals and animal-free methods in scientific research. Among the various stakeholders involved in the debate are the scientists.
Judith Regina Homberg, Aldert H. Piersma, Aldert H. Piersma, Cyrille A. M. Krul, Lisa Genzel, Anne Kienhuis, Ellen ter Gast, Monique Wolvekamp   +7 more
doaj   +1 more source