Results 51 to 60 of about 208,116 (260)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
INTELIGENCIA ARTIFICIAL HÍBRIDA. UNA AMENAZA A LATINOAMÉRICA
Revistas Argentina de Medicina, 2018 En el último tiempo existe una gran promoción de la llamada inteligencia artificial híbrida, la fusión de nuestro cerebro con implantes cerebrales. Se afirma que la inteligencia artificial híbrida es un beneficio para la sociedad; sin embargo, no se ...
David Salinas Flores
doaj +2 more sources
Teksty Drugie, 2023 The author indicates a writer’s and anthropological self-awareness that can be constructed in opposition to the neoliberal management of humanities, namely against recommendations to “write a lot.” Therefore, the article presents ways of writing and ...
Tomasz Rakowski
doaj
Virtual commander’s operational decision-making model based on thinking simulation [PDF]
Zhihui kongzhi yu fangzhenFocusing on the urgent need of joint operational plan simulation experimentation, aiming at the lack of intelligent decision-making ability of command entity in the current joint operations simulation systems, and the difficulty of popularizing the ...
JIA Chenxing, MING Yuewei, GE Chenglong
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Effects of Human Behavior Simulation on Architecture Major Students′ Fire Egress Planning
Journal of Asian Architecture and Building Engineering, 2018 This study examines the previously unknown relationship between using human behavior simulation, equipped autonomous, intelligent Virtual-Users, and students′ self-experimentation performance in fire egress planning.
Seung Wan Hong, Yun Gil Lee
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source