Results 31 to 40 of about 207,063 (262)

The Ups and Downs of the Declaration of Helsinki: The Case of the Placebo

Perspectivas Metodológicas​
The Declaration of Helsinki, adopted in 1964 by the World Medical Association, is an ethical benchmark for research involving human subjects. Throughout its successive revisions, it has faced debates and controversies around several of its articles. This
María Fernanda Sabio
doaj   +1 more source

The scientific imperative: why human-centered models must replace animal experimentation? [PDF]

Brazilian Journal of Biology
This paper aims to deconstruct the ethical and scientific impasse of using animals in biomedical research by proposing a paradigm shift towards human-centered methodologies.
Iván Vargas-Chaves
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

“PEI-ICF PETRA”: a smart web platform to foster cooperation in drafting the individualized Education Plan (IEP) for students with disability

Cogent Education
The implementation of the framework offered by the international classification of functioning disability and health (ICF) is recognized as a necessary step in the process of school inclusion for pupils with disabilities.
C. Scapin, S. Cramerotti, S. von Prondzinki, P. Folegani, A. Frascari, A. Martinuzzi   +5 more
doaj   +1 more source

Human exhaled air energy harvesting with specific reference to PVDF film

Engineering Science and Technology, an International Journal, 2017
Spirometer is a medical equipment used to measure lung capacity of a human being. It leads to diagnosis of several diseases. The researchers worked on harvesting energy from human exhalation while carrying out measurements using spirometer.
Manisha Rajesh Mhetre, Hemant Keshav Abhyankar   +1 more
doaj   +1 more source

Animals in Moral Limbo: How Literary Pigs May Help Lab-Generated Ones

Animals, 2020
When considering that artistic and literary artifacts reflect the cultural views and mores of a particular time period, there is a significant misalignment between stories depicting increased moral status of pigs (e.g., vis-à-vis human-porcine ...
Nancy Tuck
doaj   +1 more source

Experimental renewal in human participants.

Journal of Experimental Psychology: Animal Behavior Processes, 2011
Two experiments with human participants are presented that differentiate renewal from other behavioral effects that can produce a response after extinction. Participants played a video game and learned to suppress their behavior when sensor stimuli predicted an attack.
James Byron Nelson, María del Carmen Sanjuan, Sandra Vadillo-Ruiz, Joana Pérez, Samuel P. León   +4 more
openaire   +5 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections

Advanced Science, 2023
In the development of orally inhaled drug products preclinical animal models regularly fail to predict pharmacological as well as toxicological responses in humans.
Patrick Carius, Annemarie Jungmann, Marco Bechtel, Alexander Grißmer, Annette Boese, Gilles Gasparoni, Abdulrahman Salhab, Ralf Seipelt, Klaus Urbschat, Clémentine Richter, Carola Meier, Denisa Bojkova, Jindrich Cinatl, Jörn Walter, Nicole Schneider‐Daum, Claus‐Michael Lehr   +15 more
doaj   +1 more source