Results 31 to 40 of about 741,034 (292)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Compreensão do termo de consentimento em pesquisa clínica

Revista Bioética
Resumo O termo de consentimento livre e esclarecido (TCLE) é documento onde se explicita o consentimento do participante, contendo todas as informações necessárias para que seja elucidada a pesquisa da qual se propõe participar. O objetivo deste trabalho
Clarissa de Assumpção, Nínive da Silva Pinto, Luis Guillermo Coca Velarde, Osvaldo José Moreira do Nascimento, Beni Olej   +4 more
doaj   +1 more source

The ethics of AI-assisted warfighter enhancement research and experimentation: Historical perspectives and ethical challenges

Frontiers in Big Data, 2022
The military applications of AI raise myriad ethical challenges. Critical among them is how AI integrates with human decision making to enhance cognitive performance on the battlefield.
Jonathan Moreno, Michael L. Gross, Jack Becker, Blake Hereth, Neil D. Shortland, Nicholas G. Evans   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Ups and Downs of the Declaration of Helsinki: The Case of the Placebo

Perspectivas Metodológicas​
The Declaration of Helsinki, adopted in 1964 by the World Medical Association, is an ethical benchmark for research involving human subjects. Throughout its successive revisions, it has faced debates and controversies around several of its articles. This
María Fernanda Sabio
doaj   +1 more source

The scientific imperative: why human-centered models must replace animal experimentation? [PDF]

Brazilian Journal of Biology
This paper aims to deconstruct the ethical and scientific impasse of using animals in biomedical research by proposing a paradigm shift towards human-centered methodologies.
Iván Vargas-Chaves
doaj   +1 more source

Acculturating human experimentation: an empirical survey in France [PDF]

, 2001
International audiencePreliminary results of an empirical study of human experimentation practices are presented and contrasted with those of a survey conducted a hundred years ago when clinical research, although tolerated, was culturally deviant.
Amiel, P., Fagot-Largeault, Anne, Mathieu, Séverine   +2 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Interrogation or Experimentation? Assessing Non-Consensual Human Experimentation During the War on Terror [PDF]

, 2018
The prohibition against non-consensual human experimentation has long been considered sacrosanct. It traces its legal roots to the Nuremberg trials although the ethical foundations dig much deeper.
Aceves, William J.
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source