Results 31 to 40 of about 7,831,859 (299)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Nature and Context of Exploratory Experimentation: An Introduction to Three Case Studies of Exploratory Research [PDF]
, 2007 : My aim in this article is to introduce readers to the topic of exploratory experimentation and briefly explain how the three articles that follow, by Richard Burian, Kevin Elliott, and Maureen O’Malley advance our understanding of the nature and ...
Waters, C. Kenneth
core
The Ups and Downs of the Declaration of Helsinki: The Case of the Placebo
Perspectivas MetodológicasThe Declaration of Helsinki, adopted in 1964 by the World Medical Association, is an ethical benchmark for research involving human subjects. Throughout its successive revisions, it has faced debates and controversies around several of its articles. This
María Fernanda Sabio
doaj +1 more source
The scientific imperative: why human-centered models must replace animal experimentation? [PDF]
Brazilian Journal of BiologyThis paper aims to deconstruct the ethical and scientific impasse of using animals in biomedical research by proposing a paradigm shift towards human-centered methodologies.
Iván Vargas-Chaves
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Towards Algorithms for Autonomous Experimentation
, 2009 1 Introduction Modelling biological systems, is impaired by the cost of experimentally obtaining the data required to build the models. The resources available are typically very limited compared to large experimental parameter spaces, so have to be used
Lovell, C. J., Zauner, K.-P.
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Biomedical researches and ethics
Cerrahpaşa Medical Journal, 2014 The parallel faced problems since 20th century; topics of science, research and publication ethics have been started to take seriously nowadays. Especially in biomedical field, lots of historical examples for “putting society’s benefits before the ...
Gülten DİNÇ
doaj
Cogent EducationThe implementation of the framework offered by the international classification of functioning disability and health (ICF) is recognized as a necessary step in the process of school inclusion for pupils with disabilities.
C. Scapin +5 more
doaj +1 more source
Human exhaled air energy harvesting with specific reference to PVDF film
Engineering Science and Technology, an International Journal, 2017 Spirometer is a medical equipment used to measure lung capacity of a human being. It leads to diagnosis of several diseases. The researchers worked on harvesting energy from human exhalation while carrying out measurements using spirometer.
Manisha Rajesh Mhetre +1 more
doaj +1 more source