Results 21 to 30 of about 207,063 (262)

Increased PIO2 at exhaustion in hypoxia enhances muscle activation and swiftly relieves fatigue: a placebo or a PIO2 dependent effect?

Frontiers in Physiology, 2016
To determine the level of hypoxia from which muscle activation (MA) is reduced during incremental exercise to exhaustion (IE), and the role played by PIO2 in this process, ten volunteers (21±2 years) performed four IE in severe acute hypoxia (SAH) (PIO2 ...
Rafael Torres-Peralta, Rafael Torres-Peralta, José Losa-Reyna, José Losa-Reyna, David Morales-Alamo, David Morales-Alamo, Miriam Gonzalez-Izal, Ismael Pérez-Suárez, Ismael Pérez-Suárez, Jesús Gustavo Ponce-González, Mikel Izquierdo, José A Lopez Calbet, José A Lopez Calbet   +12 more
doaj   +1 more source

Ética e pesquisa

Acta Cirúrgica Brasileira, 2008
OBJETIVO: O presente artigo tem por objetivo explanar os aspectos éticos das experimentações em seres humanos e animais. CONTEÚDO: O tema abordado é de suma importância, pois almeja-se que o ser humano atinja seu bem-estar físico, mental, social e ...
Taylor Brandão Schnaider
doaj   +1 more source

Experimentation as a didactic strategy in science teaching with elementary school students

Diversitas Journal, 2023
Science Teaching has been discussed in the educational field regarding its methodological strategies on how to improve experimental activities that arouse students' curiosity and, consequently, stimulate practical teaching that is different from ...
Rosineide Nascimento da Silva, Rosane Karine Tavares Idalino, Janimara Marques da Silva   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Compreensão do termo de consentimento em pesquisa clínica

Revista Bioética
Resumo O termo de consentimento livre e esclarecido (TCLE) é documento onde se explicita o consentimento do participante, contendo todas as informações necessárias para que seja elucidada a pesquisa da qual se propõe participar. O objetivo deste trabalho
Clarissa de Assumpção, Nínive da Silva Pinto, Luis Guillermo Coca Velarde, Osvaldo José Moreira do Nascimento, Beni Olej   +4 more
doaj   +1 more source

The ethics of AI-assisted warfighter enhancement research and experimentation: Historical perspectives and ethical challenges

Frontiers in Big Data, 2022
The military applications of AI raise myriad ethical challenges. Critical among them is how AI integrates with human decision making to enhance cognitive performance on the battlefield.
Jonathan Moreno, Michael L. Gross, Jack Becker, Blake Hereth, Neil D. Shortland, Nicholas G. Evans   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source