Results 171 to 180 of about 4,017,875 (268)

Prevention and Management of Percutaneous Coronary Intervention-Related Complications: Assessing the Impact of Simulation-Based Learning and Human Factors Training. [PDF]

Catheter Cardiovasc Interv
Fukamizu J, MacCarthy T, Shimizu I, Ariura S, Tanetani R, Arahira S, Tamura M, Masamune K, Mahadevan K, Chandramohan N, Hovasse T, Monsegu J, Nolan J, Kefer J, Musialek P, Oberhoff M, Haude M, Benamer H, Muller O, Calvert PA, Sumitsuji S, O'Kane P, Toth G, Cuisset T, Wijns W, Johnson TW.   +25 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Seeking a common human factors language for the development and testing of injection devices. [PDF]

Drug Deliv
Conrad MO, Laird ME, Privitera MB, Lemke MR, Follette Story M.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Using tDCS to Investigate Fear Extinction in a Large Population of Healthy Volunteers

Brain Stimulation
Michael Nitsche, Yuanbo Ma, Giorgi Batzikadse, Fujia Jiao, Fatemeh Yavari   +4 more
doaj   +1 more source

Human factors validation study of an artificial neural network‑based preoperative decision‑support tool for noninvasive lymph node staging (NILS) in women with primary breast cancer (ISRCTN99301435). [PDF]

BMC Cancer
Allfelt A, Bendahl PO, Dihge L, Ohlsson M, Rydén L, Skarping I.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Challenges and Opportunities in the Medication Reconciliation Process in an Emergency Department: An Observational Human Factors Study. [PDF]

J Patient Saf
Chen HW, Wurst C, Lattimer TA, Setiowati N, Bisantz A, Wahler RG, Jacobs DM, Hewner S, Stoll J, Casucci S, Singh R.   +10 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Human factors in difficult airway management: An anaesthetist's perspective. [PDF]

Natl J Maxillofac Surg
Mohanty PK.
europepmc   +1 more source